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Update on the Role of Chest Imaging in Cystic Fibrosis. | LitMetric

Update on the Role of Chest Imaging in Cystic Fibrosis.

Radiographics

From the Mallinckrodt Institute of Radiology (S.M.B, J.C.E.G, S.B.) and Department of Medicine (D.B.R.), Washington University, 660 S Euclid Ave, St. Louis, MO 63110.

Published: September 2024

AI Article Synopsis

  • Recent advancements in treatment, including modulator therapies targeting the genetic defect, have significantly improved lung function and overall quality of life for patients.
  • The article emphasizes the importance of updated imaging guidelines and technologies for better monitoring and early detection of lung complications in cystic fibrosis, highlighting the need for radiologists to stay informed on these developments.

Article Abstract

Cystic fibrosis is a genetic disease with multisystem involvement and associated morbidity and mortality that are most directly related to progressive lung disease. The hallmark findings of cystic fibrosis in the lungs are chronic inflammation and infection, leading to progressive loss of pulmonary function and often requiring lung transplant. Predominant lung findings include mucous plugging, bronchiectasis, and air trapping, often with associated atelectasis, consolidation, and emphysema; these findings form the basis of several clinical scoring systems that are used for imaging assessment. Recently, there have been major breakthroughs in the pharmacologic management of cystic fibrosis, including highly effective modulator therapies that directly target the underlying cystic fibrosis transmembrane conductance regulator molecular defect, often leading to remarkable improvements in lung function and quality of life with corresponding significant improvements in imaging markers. The authors review current guidelines regarding cystic fibrosis with respect to disease monitoring, identifying complications, and managing advanced lung disease. In addition, they discuss the evolving role of imaging, including current trends, emerging technologies, and proposed updates to imaging guidelines endorsed by international expert committees on cystic fibrosis, which favor increased use of cross-sectional imaging to enable earlier detection of structural changes in early disease and more sensitive detection of acute changes in advanced disease. It is important for radiologists to be familiar with these trends and updates so that they can most effectively assist clinicians in guiding the management of patients with cystic fibrosis in all stages of disease. RSNA, 2024.

Download full-text PDF

Source
http://dx.doi.org/10.1148/rg.240008DOI Listing

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