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| http://dx.doi.org/10.1001/jamanetworkopen.2024.28953 | DOI Listing |
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Case Report: Nephrocalcinosis in an infant due to vitamin-D food supplement overdose.
Front Pediatr
November 2024
Hospital Pharmacy, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella, Italy.
Article Synopsis
- Vitamin D is crucial for calcium regulation and overall health, with infants needing 400 IU daily, but the supplement market lacks consistent regulations that can lead to risks.
- A case study of a 22-month-old girl shows how an overdose—25 times the recommended dosage—led to nephrocalcinosis and various symptoms due to excessive vitamin D intake from an online supplement.
- This incident underscores the dangers of self-administering vitamin D without medical supervision, highlighting the need for cautious healthcare guidance on vitamin D supplementation.
Article Synopsis
- A four-year-old girl experienced persistent hypoglycemia shortly after birth and was diagnosed with congenital hyperinsulinism due to genetic mutations in the ABCC8 gene.
- She did not respond to typical treatments like oral diazoxide but showed improvement with subcutaneous somatostatin injections.
- At age three and a half, her treatment was changed to a long-acting somatostatin analogue, leading to better blood sugar control, normal growth, and the ability to stop tube feeding.
Preventive Effects of a CVD Polypill on Developing Diabetes Among Patients With Metabolic Syndrome: Results of the PolyIran-Liver Trial.
Arch Iran Med
October 2024
Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background: While cardiovascular disease (CVD) polypills have demonstrated significant benefits in preventing CVD events by managing CVD risk factors and improving patient adherence, their effects on blood glucose levels, an important risk factor for CVD, remain unknown.
Methods: We analyzed data from the PolyIran-Liver trial, which involved 1,508 participants aged 50 and above. Of these, 787 were randomly assigned to receive a polypill (consisting of aspirin, atorvastatin, hydrochlorothiazide, and valsartan), while 721 received usual care as the control group over a five-year period.
Bladder Symptoms Provoked by Short, Rapid-Acting Loop Diuretics: A Frequent but Often Overlooked Problem.
Am J Hypertens
January 2025
Sarfez Inc, Vienna, Virginia, USA.
Background: Bladder dysfunction entails overactive bladder (OAB) defined as symptoms of urinary urgency, frequency, and/or nocturia with or without incontinence if there is no obvious pathology or infection or lower urinary tract symptoms that includes recognized causes of bladder dysfunction.
Methods: Literature search.
Results: Symptoms of OAB are reported in about 15% of the adult US population.
[The delapril-indapamide combination in treatment of arterial hypertension: practical implications in light of the new guidelines.].
Recenti Prog Med
October 2024
Dipartimento di Cardiologia, Ospedale Santa Maria della Misericordia, Perugia.
The recent guidelines issued by the European Society of Hypertension reaffirmed that the degree of control of hypertension remains suboptimal worldwide. In order to increase the proportion of well-controlled patients, in addition to nonpharmacological measures, it is necessary to improve the implementation of drug therapy in the clinical practice as much as possible. Initial therapy should almost always be based on the combination, free or fixed, between ACE inhibitor drugs, or direct angiotensin II inhibitors ('sartans') and diuretics (thiazide or thiazide-like) or calcium channel blockers at the maximum recommended and well-tolerated dose.
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