AI Article Synopsis
- - The study investigates the relationship between the CagA gene and chronic gastritis in a Chinese population, focusing on variations in the EPIYA motifs and their impact on disease severity.
- - Researchers isolated 86 strains of CagA-positive bacteria from patients with chronic gastritis in Beijing, using PCR to analyze the genetic sequences, identifying 259 EPIYA motifs with notable variations among different types of CagA.
- - The findings indicate that the CagA-ABD type is most prevalent and may be associated with more severe forms of gastric conditions, highlighting significant differences between East-Asian and Western types of CagA in terms of EPIYA segment variations.
Article Abstract
. Cytotoxin-associated gene A (CagA) from is highly related to chronic gastritis. Tyrosine phosphorylation of Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs from CagA determines the pathogenicity of .. The precise amino acid variations surrounding the EPIYA motifs and their correlation with clinical outcomes have been poorly explored.. The purpose of this study was to examine the CagA 3' region polymorphism of and its association with chronic gastritis in the Chinese population.. A total of 86 -positive strains were isolated from patients with chronic gastritis in two different hospitals in Beijing, PR China. Genomic DNA was extracted commercial kits, and the 3' variable region of was amplified by polymerase chain reaction (PCR). The PCR products were sequenced and analysed using the CLC Sequence Viewer, BioEdit, and WebLogo 3.. Two hundred and fifty-nine EPIYA motifs were identified from -positive strains. Notably, EPIYA-B exhibited a higher frequency of variation in comparison to EPIYA-A, EPIYA-C, and EPIYA-D. The prevalent sequences for East-Asian-type CagA were QVNK and TIDF, while KVNK and TIDD were most commonly observed for Western-type CagA. The CRPIA motifs of East-Asian-type CagA and Western-type CagA varied at positions 4, 6, 7, 8, and 10. CagA-ABD (73.2%) was the most prevalent type, followed by CagA-ABC (18.6%) and CagA-AB (3.4%). The ratio of CagA-ABD was observed to be higher in cases of chronic non-atrophic gastritis with erosive (NAGE) or chronic atrophic gastritis (AG) compared to chronic non-atrophic gastritis (NAG), and the difference was found to be statistically significant (χ2=59.000/64.000, <0.001).. The EPIYA segments of Western-type CagA and East-Asian-type CagA differ significantly and the presence of CagA-ABD may be associated with severe chronic gastritis from this study.
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