AI Article Synopsis
- - Fenamates, known for their use as nonsteroidal anti-inflammatory agents, show promise in cancer prevention and treatment based on preclinical studies and epidemiological data, though comprehensive reviews on their role are scarce.
- - This review focuses on fenamates’ effectiveness alone and in combination with other chemotherapy drugs, examining their various targets in cancer therapy, including important pathways and proteins involved in tumor growth and immune response.
- - Additionally, the paper discusses structural changes in fenamates that could enhance their anticancer properties, suggesting that they may serve as potential leads for new cancer treatments.
Article Abstract
Fenamates as classical nonsteroidal anti-inflammatory agents are widely used for relieving pain. Preclinical studies and epidemiological data highlight their chemo-preventive and chemotherapeutic potential for cancer. However, comprehensive reviews of fenamates in cancer are limited. To accelerate the repurposing of fenamates, this review summarizes the results of fenamates alone or in combination with existing chemotherapeutic agents. This paper also explores targets of fenamates in cancer therapy, including COX, AKR family, AR, gap junction, FTO, TEAD, DHODH, TAS2R14, ion channels, and DNA. Besides, this paper discusses other mechanisms, such as regulating Wnt/β-catenin, TGF-β, p38 MAPK, and NF-κB pathway, and the regulation of the expressions of Sp, EGR-1, NAG-1, ATF-3, ErbB2, AR, as well as the modulation of the tumor immune microenvironment. Furthermore, this paper outlined the structural modifications of fenamates, highlighting their potential as promising leads for anticancer drugs.
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| http://dx.doi.org/10.1002/med.22079 | DOI Listing |
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