AI Article Synopsis
- Bilateral head and neck paragangliomas (HNPGLs) need careful management to balance tumor control and preserving nerve function.
- A study from 1983 to 2023 analyzed 49 patients with 116 tumors and found younger patients and jugular paragangliomas were more frequently treated with surgery.
- Carotid body tumors (CBTs) showed a lower risk of postoperative cranial nerve deficits compared to vagal and jugular paragangliomas.
Article Abstract
Background: Bilateral head and neck paragangliomas (HNPGLs) require nuanced management to balance tumor control with functional preservation.
Methods: All patients seen at a single-institution for bilateral paraganglioma between 1983 and 2023 were retrospectively reviewed. Demographics, genetic testing results, and tumor characteristics were analyzed and compared to treatment modality and cranial nerve outcomes.
Results: There were 49 patients with 116 tumors (90 carotid body tumors [CBTs], 15 vagal paragangliomas [VPs], and 11 jugular paragangliomas [JPs]). Twenty-six patients had SDH pathologic variants (PV). Surgical management was more commonly utilized in younger patients (OR: 0.97, 95% CI: 0.950-0.992) and for JPs (OR: 9, 95% CI: 1.386-58.443). In surgical cases, CBTs had a lower risk of postoperative cranial nerve deficits compared to JPs and VPs (OR: 0.095, 95% CI: 0.013-0.692).
Conclusions: Younger patients with bilateral HNPGLs, especially those with JP and CBT, are more often treated with surgery. CBTs have lowest risk of cranial nerve deficits after surgery.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635744 | PMC |
| http://dx.doi.org/10.1002/hed.27923 | DOI Listing |
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