Synthetic biology approaches and bioseparations in syngas fermentation.

Trends Biotechnol

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India. Electronic address:

Published: January 2025

AI Article Synopsis

  • Fossil fuels contribute significantly to greenhouse gas emissions and climate change, emphasizing the need for sustainable alternatives like biomass-derived syngas.
  • Syngas, primarily composed of hydrogen and carbon monoxide, is created through biomass gasification and can address environmental issues.
  • The review discusses advancements in genetic tools and metabolic engineering to enhance syngas fermentation processes, along with challenges in scaling up, microorganism interactions, and commercial viability.

Article Abstract

Fossil fuel use drives greenhouse gas emissions and climate change, highlighting the need for alternatives like biomass-derived syngas. Syngas, mainly H and CO, is produced via biomass gasification and offers a solution to environmental challenges. Syngas fermentation through the Wood-Ljungdahl pathway yields valuable chemicals under mild conditions. However, challenges in scaling up persist due to issues like unpredictable syngas composition and microbial fermentation contamination. This review covers advancements in genetic tools and metabolic engineering to expand product range, highlighting crucial enabling technologies that expedite strain development for acetogens and other non-model organisms. This review paper provides an in-depth exploration of syngas fermentation, covering microorganisms, gas composition effects, separation techniques, techno economic analysis, and commercialization efforts.

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Source
http://dx.doi.org/10.1016/j.tibtech.2024.07.008DOI Listing

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