AI Article Synopsis
- Coffee contains bioactive compounds like caffeine and chlorogenic acid that may protect against neurodegenerative disorders, particularly Alzheimer's disease (AD).
- Research indicates these compounds influence key processes involved in AD, such as amyloid and tau buildup, as well as neuroinflammation.
- Moderate coffee consumption (2-3 cups daily) has been associated with a reduced risk of AD and may also provide anticancer and anti-inflammatory benefits.
Article Abstract
Coffee, a universally consumed beverage, is known to contain thousands of bioactive constituents that have garnered interest due to their potential neuroprotective effects against various neurodegenerative disorders, including Alzheimer's disease (AD). Extensive research has been conducted on coffee constituents such as Caffeine, Trigonelline, Chlorogenic acid, and Caffeic acid, focusing on their neuroprotective properties. These compounds have potential to impact key mechanisms in AD development, including amyloidopathy, tauopathy, and neuroinflammation. Furthermore, apart from its neuroprotective effects, coffee consumption has been associated with anticancerogenic and anti-inflammatory effects, thereby enhancing its therapeutic potential. Studies suggest that moderate coffee intake, typically around two to three cups daily, could potentially contribute to mitigating AD progression and lowering the risk of related neurological disorders. This literature underscores the potential neuroprotective properties of coffee compounds, which usually perform their neuronal protective effects via modulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), nuclear factor erythroid-derived 2-like 2 (Nrf2), interleukins, tumor necrosis factor-alpha (TNF-α), and many other molecules.
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| http://dx.doi.org/10.1016/bs.pbr.2024.06.002 | DOI Listing |
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