AI Article Synopsis
- The study focused on the fungus Stereum hirsutum, leading to the extraction of 12 isopentenyl benzene derivatives, including six new compounds named stereuins A-F.
- The structures of these compounds were confirmed using NMR and mass spectrometry, with stereuins A-C being benzoate derivatives that include fatty acid components.
- Stereuin A showed potential for promoting nerve cell growth in vitro, while compounds D-F demonstrated antibacterial properties against Staphylococcus aureus, with stereuin F being nearly as effective as penicillin G.
Article Abstract
Cultivation and extraction of the fungus Stereum hirsutum (Willd.) Pers. yielded 12 isopentenyl benzene derivatives, including six previously undescribed derivatives, named stereuins A-F. Their structures were established based on NMR and mass spectroscopy analyses, supplemented by comparison with previously reported data. Stereuins A-C are unique benzoate derivatives containing fatty acid subunits. Stereuins D and E feature a valylene group and a 6/6/6 ring system. In vitro, stereuin A significantly promoted neurite outgrowth. Several compounds exhibited antibacterial activity against Staphylococcus aureus. Stereuin F has an IC value of 5.2 μg/mL against S. aureus, comparable to the positive control, penicillin G sodium (1.4 μg/mL).
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| http://dx.doi.org/10.1016/j.phytochem.2024.114253 | DOI Listing |
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