Background: While patients affected by mild cognitive impairment (MCI) exhibit characteristic voxel-mirrored homotopic connectivity (VMHC) alterations, the ability of such VMHC abnormalities to predict the diagnosis of MCI in these patients remains uncertain. As such, this study was performed to evaluate the potential role of VMHC abnormalities in the diagnosis of MCI.
Methods: MCI patients and healthy controls (HCs) were enrolled and subjected to resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing. VMHC and support vector machine (SVM) techniques were then used to examine the collected imaging data.
Results: Totally, 53 MCI patients and 68 healthy controls were recruited. Compared to HCs, MCI patients presented with an increase in postcentral gyrus VMHC. SVM classification demonstrated the ability of postcentral gyrus VMHC values to classify HCs and MCI patients with accuracy, sensitivity, and specificity values of 63.64 %, 71.69 %, and 89.71 %, respectively.
Conclusion: VMHC abnormalities in the postcentral gyrus may be mechanistically involved in the pathophysiological progression of MCI patients, and these abnormal VMHC patterns may also offer utility as a neuroimaging biomarker for MCI patient diagnosis.
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http://dx.doi.org/10.1016/j.exger.2024.112547 | DOI Listing |
Am J Geriatr Psychiatry
December 2024
Department of Psychiatry and Human Behavior (RJC), Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA.
Objective: To investigate the effects of discordant medication beliefs on diabetes self-management and glycemic control in older Black individuals with diabetes and Mild Cognitive Impairment (MCI).
Methods: Cross-sectional analysis of baseline data from two clinical trials testing behavioral interventions to improve glycemic control in older Black primary care patients with diabetes and MCI.
Results: The mean number of discordant medication beliefs was 6 (SD = 3; range 0 to 16).
World J Psychiatry
December 2024
Department of Geriatrics, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, Jiangsu Province, China.
Background: Mild cognitive impairment (MCI) in elderly individuals is a transitional stage between normal cognition and dementia. Understanding the risk factors for MCI and identifying those at high risk are extremely important for the elderly population.
Aim: To analyze the risk factors for MCI in the elderly population and construct a clinical prediction model.
Front Aging Neurosci
December 2024
Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
Background: Neurofilament light chain (NfL) has recently emerged as a key indicator of neurodegeneration. In this study, our hypothesis is that the levels of blood-derived NfL and its accumulation during the Parkinson's disease (PD) progression could serve as a potential biomarker for predicting subsequent cognitive decline. To investigate this, we conducted a study utilizing a large single-center cohort.
View Article and Find Full Text PDFNeurology
January 2025
From the IRCCS Neuromed (M.I.D.B., G.L., S.P., A.C., A.B., G.F., P.P., D.B.), Pozzilli; Department of Human Neurosciences (A.O., G.L., C.P., S.P., M.C., F.D.A., S.B., R.M., G.B., A.C., A.B., G.F., P.P., D.B.), Sapienza University of Rome; Department of Microscopic and Ultrastructural Anatomy (G.V.), Campus Biomedico University of Rome; Department of Neuroscience (M.C.), Istituto Superiore di Sanità, Rome; and Cognitive and Motor Rehabilitation and Neuroimaging Unit (F.D.A.), IRCCS Fondazione Santa Lucia, Rome, Italy.
Background And Objectives: According to the dual syndrome hypothesis, patients with Parkinson disease (PD) with visuospatial deficits are more likely to progress to dementia, compared with patients with a prevalent dysexecutive syndrome. In this study, we aimed to investigate whether early connectivity changes in the dorsolateral prefrontal cortex (DLPFC) and the precuneus (PCun)-which are critical to fronto-executive and visuospatial functions, respectively-can identify distinct cognitive phenotypes in cognitively intact newly diagnosed patients with PD.
Methods: Newly diagnosed, drug-naïve patients with PD (≤2 years from clinical onset) with normal Montreal Cognitive Assessment (MoCA), were consecutively enrolled from our Movement Disorders Clinics in Italy.
Neurol Ther
December 2024
Columbia University, 630 W 168Th St (P&S Unit 16), New York, NY, 10032, USA.
Introduction: The availability of anti-amyloid therapy for mild cognitive impairment (MCI) due to Alzheimer's disease and mild Alzheimer's dementia (AD) has underscored the need for realistic estimates of the population with AD/MCI within the healthcare system to assure adequate preparedness. We hypothesize that administrative databases can provide real-world epidemiologic estimates reflecting the population with diagnosed (known) MCI and AD. This study was conducted to estimate diagnostic incidence and prevalence of AD and all-cause MCI among the Medicare fee-for-service (FFS) and Medicare Advantage (MA) beneficiaries in the United States.
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