Objective: To evaluate the effect of 3.5-mm locking compression plate (LCP) length on construct stiffness and plate and bone model strain in a synthetic, short-fragment, fracture-gap model.
Study Design: Six replicates of 6-hole, 8-hole, 10-hole, and 12-hole LCP constructs on a short-fragment, tubular Delrin fracture gap model underwent four-point compression and tension bending. Construct stiffness and surface strain, calculated using three-dimensional digital image correlation, were compared across plate length and region of interest (ROI) on the construct.
Results: The 12-hole plates (80% plate-bone ratio) had significantly higher construct stiffness than 6-hole, 8-hole, and 10-hole plates and significantly lower plate strain than 6-hole plates at all ROIs. Strain on the bone model was significantly lower in constructs with 10-hole and 12-hole plates than 6-hole plates under both compression and tension bending.
Conclusion: Incremental increases in construct stiffness and incremental decreases in plate strain were only identified when comparing 6-hole, 8-hole, and 10-hole plates to 12-hole plates, and 6-hole to 12-hole plates, respectively. Strain on the bone model showed an incremental decrease when comparing 6-hole to 10-hole and 12-hole plates. A long plate offered biomechanical advantages of increased construct stiffness and reduced plate and bone model strain, over a short plate in this in vitro model.
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http://dx.doi.org/10.1055/s-0044-1789263 | DOI Listing |
Int J Biol Macromol
January 2025
Department of Pharmaceutical Analysis, Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, The School of Pharmacy, Fujian Medical University, Fuzhou 350122, China. Electronic address:
Since cartilage injury is often accompanied by subchondral bone damage, conventional single-phase materials cannot accurately simulate the osteochondral structure or repair osteochondral injury. In this work, a gradient gelatin-methacryloyl (GelMA) hydrogel scaffold was constructed by a layer-by-layer stacking method to realize full-thickness regeneration of cartilage, calcified cartilage and subchondral bone. Of note, to surmount the inadequate mechanical property of GelMA hydrogel, nanohydroxyapatite (nHA) was incorporated and further functionalized with hydroxyethyl methacrylate (nHA-hydroxyethyl methacrylate, nHAMA) to enhance the interfacial adhesion with the hydrogel, resulting in better mechanical strength akin to human bone.
View Article and Find Full Text PDFWearable Technol
December 2024
Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, USA.
This work studies upper-limb impairment resulting from stroke or traumatic brain injury and presents a simple technological solution for a subset of patients: a soft, active stretching aid for at-home use. To better understand the issues associated with existing associated rehabilitation devices, customer discovery conversations were conducted with 153 people in the healthcare ecosystem (60 patients, 30 caregivers, and 63 medical providers). These patients fell into two populations: spastic (stiff, clenched hands) and flaccid (limp hands).
View Article and Find Full Text PDFJ Inflamm Res
January 2025
Department of Shandong Trauma Center, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, 250014, People's Republic of China.
Background: Posttraumatic elbow stiffness is a complex complication with two characteristics of capsular contracture and heterotopic ossification. Currently, genomic mechanisms and pathogenesis of posttraumatic elbow stiffness remain inadequately understood. This study aims to identify differentially expressed genes (DEGs) and elucidate molecular networks of posttraumatic elbow stiffness, providing novel insights into disease mechanisms at transcriptome level.
View Article and Find Full Text PDFThe tumor microenvironment (TME) is critical for cancer initiation, growth, metastasis, and therapeutic resistance. The extracellular matrix (ECM) is a significant tumor component that serves various functions, including mechanical support, TME regulation, and signal molecule generation. The quantity and cross-linking status of ECM components are crucial factors in tumor development, as they determine tissue stiffness and the interaction between stiff TME and cancer cells, resulting in aberrant mechanotransduction, proliferation, migration, invasion, angiogenesis, immune evasion, and treatment resistance.
View Article and Find Full Text PDFJ ISAKOS
January 2025
Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA. Electronic address:
Objectives: To compare the biomechanical strength and stiffness of the native posteromedial and posterolateral meniscotibial ligament complex (MTLC) to suture anchor repair of the MTLC.
Methods: Biomechanical testing was performed on 24 fresh-frozen pediatric human knees. Four conditions were tested: native posteromedial MTLC (n=14), native posterolateral MTLC (n=14), posteromedial MTLC repair (n=5), and posterolateral MTLC repair (n=5).
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