AI Article Synopsis
- Hemorrhage is a major cause of death, and blood products, particularly low titer group O whole blood (LTOWB), are increasingly used to treat patients with hemorrhagic shock.
- A study analyzed data from over 12,000 trauma patients, finding that 30% received LTOWB within the first 4 hours after hospital arrival.
- Results indicated that while LTOWB did not show a survival difference at 6 hours, patients receiving at least 10% of LTOWB relative to total blood products had a higher chance of surviving for 24 hours.
Article Abstract
Introduction: Hemorrhage is a leading cause of death. Blood products are used for the treatment of hemorrhagic shock. The use of low titer group O whole blood (LTOWB) has become more common.
Methods: Data from patients ≥15 years of age in the Trauma Quality Improvement Program (TQIP) database that received ≥10 units of packed red cells and/or LTOWB within the first 4-h of hospital arrival were included. The proportion of LTWOB of total blood products administered was correlated to 6- and 24-h mortality.
Results: 12,763 met inclusion, 3827 (30 %) received LTOWB. On multivariable logistic regression (MVLR), there was no difference in survival at 6 h with a LTOWB. When assessing 24-h survival, there was improved survival with LTOWB ≥10 % (OR 1.18, 1.08-1.28).
Conclusions: In this analysis of TQIP data, patients receiving ≥10 units of PRBC or LTOWB, we found that higher proportions of LTOWB transfusion relative to the total volume of blood products transfused during the first 4 h were associated with improved 24-h, but not 6-h survival.
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| http://dx.doi.org/10.1016/j.amjsurg.2024.115900 | DOI Listing |
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