Diabetes-Associated Scleredema.

N Engl J Med

Lewisham and Greenwich NHS Trust, London, United Kingdom

Published: August 2024

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http://dx.doi.org/10.1056/NEJMicm2400802DOI Listing

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Diabetes-Associated Scleredema.

N Engl J Med

August 2024

Lewisham and Greenwich NHS Trust, London, United Kingdom

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Introduction: Although type 2 diabetes mellitus (DM) is a global public health problem, the diabetes-associated dermatological (non-infectious) manifestations (DADM) remain poorly understood and under-diagnosed. We aimed to evaluate the prevalence of 7 known DADM in a primary care setting, and their association macro/microvascular complications.

Methods: Cross-sectionnal study included patients consulting in general practice for DM-follow up, from November 2016 to January 2017.

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Scleredema is a deposition disorder which presents as diffuse, symmetric, non-pitting skin induration from dermal deposits of glycosaminoglycans ("mucins"). It classically affects the upper back and posterior neck, often causing skin tightness and decreased range of motion. In most patients the clinical course is chronic and treatment options are limited.

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Scleroderma.

Dermatol Online J

October 2003

Ronald O. Perelman Department of Dermatology, New York University, USA.

A 72-year-old man with diabetes-associated scleredema is presented. The patient had a long history of diabetes mellitus that had been difficult to control with complications of retinopathy, nephropathy, and arteriosclerosis leading to myocardial infarcts and stroke. The scleredema has remained stable with 4 months of topical clobetasol ointment twice daily and biweekly physical therapy.

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Scleroedema in a child.

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Department of Dermatology, Yamagata University School of Medicine, Japan.

A 3-year-old Japanese girl with scleroedema was reported. She had had no signs of diabetes but did have a preceding bacterial infection in the tonsils three weeks before the skin lesion appeared. The skin on the face, shoulders, extensor aspect of the upper arms, and proximal half of the forearms was indurated.

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