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Multiple Model Optimal Sampling Promotes Accurate Vancomycin Area-Under-the-Curve Estimation Using a Single Sample in Critically Ill Children.
Ther Drug Monit
January 2025
Children's Hospital Los Angeles, Los Angeles, California; and.
Background: Area-under-the-curve (AUC)-directed vancomycin therapy is recommended; however, AUC estimation in critically ill children is difficult owing to the need for multiple samples and lack of informative models.
Methods: The authors prospectively enrolled critically ill children receiving intravenous (IV) vancomycin for suspected infection and evaluated the accuracy of Bayesian estimation of AUC from a single, optimally timed sample. During the dosing interval, when clinical therapeutic drug monitoring was performed, an optimally timed sample was collected, which was determined for each subject using an established population pharmacokinetic model and the multiple model optimal function of Pmetrics, a nonparametric population pharmacokinetic modeling software.
Tranexamic Acid and Heterotopic Ossification Formation Following Elbow Surgery: A Prospective Randomized Controlled Trial.
J Orthop Trauma
January 2025
The Hand and Upper Extremity Surgery Unit, Department of Orthopaedic Surgery, Yitzhak Shamir Medical Center affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tzrifin, Israel.
Objectives: This study investigates whether the intra-operative administration of intravenous tranexamic acid (TXA), known for its hemostatic and potential anti-inflammatory properties, affects the incidence of heterotopic ossification (HO) following surgery for elbow fracture-dislocations.
Methods: Design: Prospective, randomized clinical trial.
Setting: Hand and Upper Extremity Surgery Unit.
Investigating the Relationship Between Midazolam Serum Concentrations and Paediatric Delirium in Critically Ill Children.
Pediatr Rep
January 2025
Department of Pediatrics, Division of Pediatric Critical Care Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Objectives: Intravenous midazolam is widely used for sedation in critically ill children. Sometimes, these children develop a paediatric delirium (PD). Our aim was to determine the relationship between midazolam serum concentration and the development of new PD in critically ill children.
View Article and Find Full Text PDFRetrospective descriptive report comparing access systems to refine intravenous self-administration in rats.
Lab Anim
January 2025
Department of Population Health Sciences, Section Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, the Netherlands.
For operant self-administration, permanent intravenous cannulas need to remain open and operational for months without infections or blockages. Here, we report retrospectively on our experiences and observations using different access systems during three studies. We identified a refined method for vena jugularis cannulation that is a vast improvement for the animals, biotechnicians and researchers.
View Article and Find Full Text PDFLong-term ultrasonographic changes of the canine prostate gland after castration.
Front Vet Sci
January 2025
Department of Veterinary Medicine and Animal Production, University of Naples, Federico II, Naples, Italy.
Introduction: Ultrasound imaging (US) is the method of choice to assess the canine prostate gland. Whilst recent studies have documented the role of castration in the development of prostatic neoplasia, little is known about parenchymal and perfusion features of the normal and abnormal prostate in neutered dogs. No data are available concerning prostatic changes after the first 90 days following castration.
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