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The partitioning of TCR repertoires by thymic selection. | LitMetric

The partitioning of TCR repertoires by thymic selection.

J Exp Med

Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Published: October 2024

AI Article Synopsis

Article Abstract

αβ T cells are critical components of the adaptive immune system; they maintain tissue and immune homeostasis during health, provide sterilizing immunity after pathogen infection, and are capable of eliminating transformed tumor cells. Fundamental to these distinct functions is the ligand specificity of the unique antigen receptor expressed on each mature T cell (TCR), which endows lymphocytes with the ability to behave in a cell-autonomous, disease context-specific manner. Clone-specific behavioral properties are initially established during T cell development when thymocytes use TCR recognition of major histocompatibility complex (MHC) and MHC-like ligands to instruct survival versus death and to differentiate into a plethora of inflammatory and regulatory T cell lineages. Here, we review the ligand specificity of the preselection thymocyte repertoire and argue that developmental stage-specific alterations in TCR signaling control cross-reactivity and foreign versus self-specificity of T cell sublineages.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338286PMC
http://dx.doi.org/10.1084/jem.20230897DOI Listing

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