AI Article Synopsis
- A study evaluated AT2R antibody concentrations in 136 patients with various glomerular diseases and compared them to a healthy control group.
- Results showed that systemic lupus erythematosus patients had significantly higher AT2R antibody levels than controls, while other diseases did not show this difference.
- Significant correlations between AT1R and AT2R antibodies were found in patients with membranous nephropathy, IgA nephropathy, and c-ANCA vasculitis, but no link was established between AT2R levels and the disease's clinical progression.
Article Abstract
We evaluated the concentration of AT2R antibodies in 136 patients with primary and secondary glomerular diseases: membranous nephropathy (n = 18), focal and segmental glomerulosclerosis (n = 25), systemic lupus erythematosus (n = 17), immunoglobulin A (IgA) nephropathy (n = 14), mesangial (non-IgA) proliferative nephropathy (n = 6), c-ANCA vasculitis (n = 40), perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) vasculitis (n = 16), and compared it with a healthy control group (22 patients). Serum creatinine levels, proteinuria, serum albumin, and total protein concentrations were prospectively recorded for 2 years. The mean levels of AT2R antibodies in the lupus nephropathy group were significantly higher compared to the control group, 64.12 ± 26.95 units/mL and 9.72 ± 11.88 units/mL, respectively. There was no association between this level and the clinical course of the disease. The AT2R levels in other kinds of glomerular disease were no different from the control group. We found significant correlations between AT1R and AT2R in patients with membranous nephropathy (r = 0.66), IgA nephropathy (r = 0.61), and c-ANCA vasculitis (r = 0.63). Levels of AT2R antibodies in systemic lupus erythematosus are higher compared to other types of glomerulonephritis, vasculitis, and a healthy control group. Levels of AT2R antibodies correlate with AT1R antibodies in the groups of patients with membranous nephropathy, IgA nephropathy, and c-ANCA vasculitis. These kinds of AT2R antibodies have a stimulative effect on AT2R, but we have not found the influence of these antibodies on the clinical course of glomerular diseases.
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Article Synopsis
- A study evaluated AT2R antibody concentrations in 136 patients with various glomerular diseases and compared them to a healthy control group.
- Results showed that systemic lupus erythematosus patients had significantly higher AT2R antibody levels than controls, while other diseases did not show this difference.
- Significant correlations between AT1R and AT2R antibodies were found in patients with membranous nephropathy, IgA nephropathy, and c-ANCA vasculitis, but no link was established between AT2R levels and the disease's clinical progression.
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