Clinical instruments that use a filter/follow-up response format often produce data with excess zeros, especially when administered to nonclinical samples. When the unidimensional graded response model (GRM) is then fit to these data, parameter estimates and scale scores tend to suggest that the instrument measures individual differences only among individuals with severe levels of the psychopathology. In such scenarios, alternative item response models that explicitly account for excess zeros may be more appropriate. The multivariate hurdle graded response model (MH-GRM), which has been previously proposed for handling zero-inflated questionnaire data, includes two latent variables: susceptibility, which underlies responses to the filter question, and severity, which underlies responses to the follow-up question. Using both simulated and empirical data, the current research shows that compared to unidimensional GRMs, the MH-GRM is better able to capture individual differences across a wider range of psychopathology, and that when unidimensional GRMs are fit to data from questionnaires that include filter questions, individual differences at the lower end of the severity continuum largely go unmeasured. Practical implications are discussed.
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http://dx.doi.org/10.1177/01466216241261709 | DOI Listing |
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December 2024
Department of Electronics and Communication Engineering, Dronacharya Group of Institutions, Greater Noida, UP, India.
Speaker verification in text-dependent scenarios is critical for high-security applications but faces challenges such as voice quality variations, linguistic diversity, and gender-related pitch differences, which affect authentication accuracy. This paper introduces a Gender-Aware Siamese-Triplet Network-Deep Neural Network (ST-DNN) architecture to address these challenges. The Gender-Aware Network utilizes Convolutional 2D layers with ReLU activation for initial feature extraction, followed by multi-fusion dense skip connections and batch normalization to integrate features across different depths, enhancing discrimination between male and female speakers.
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December 2024
School of Chemistry, Faculty of Engineering and Physical Sciences, University of Southampton, Life Sciences Building 85, University Road, Highfield, Southampton, SO17 1BJ, UK.
Osteoarthritis (OA) is a complex disease of cartilage characterised by joint pain, functional limitation, and reduced quality of life with affected joint movement leading to pain and limited mobility. Current methods to diagnose OA are predominantly limited to X-ray, MRI and invasive joint fluid analysis, all of which lack chemical or molecular specificity and are limited to detection of the disease at later stages. A rapid minimally invasive and non-destructive approach to disease diagnosis is a critical unmet need.
View Article and Find Full Text PDFJ Racial Ethn Health Disparities
December 2024
Department of Psychiatry and Biobehavioral Sciences at the David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Objectives: Racial and ethnic differences in long-term outcomes associated with medications for opioid use disorder (MOUD) are poorly understood.
Methods: The present analyses were based on 751 participants with opioid use disorder (OUD) who were initially recruited from opioid treatment programs located in California, Connecticut, Oregon, Pennsylvania, and Washington and participated in a randomized controlled trial and at least one follow-up interview. 9.
Sci Rep
December 2024
Department of Thyroid Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, 410013, Hunan, P. R. China.
The management of papillary thyroid carcinoma (PTC) concurrent with Hashimoto's thyroiditis (HT) lacks standardized guidelines, especially concerning surgical strategies. This study aimed to compare unilateral thyroidectomy (UT) with total thyroidectomy (TT) in PTC-HT patients to optimize clinical management and improve postoperative outcomes. This retrospective study included PTC-HT patients undergoing thyroid surgery at a tertiary academic medical institution from January 2018 to August 2023.
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December 2024
Department of Gastroenterology, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan, 430060, Hubei Province, China.
Helicobacter pylori (H. pylori) is one of the most globally prevalent bacteria, closely associated with gastrointestinal diseases such as gastric ulcers and chronic gastritis. Current clinical methods primarily involve Carbon-13 and Carbon-14 urea breath test, both carrying potential safety risks.
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