Osteoarthritis (OA) of the knee is a degenerative condition impacting numerous individuals globally. Genicular artery embolization (GAE) has emerged as an effective minimally invasive therapy for managing medically refractory OA-related pain in patients who are not eligible for surgery. This intervention works by disrupting the inflammatory and neoangiogenic pathways that contribute to pain. The efficacy of GAE has been demonstrated in various clinical trials, yielding promising results. This review aims to explore recent advancements in the embolic materials used during GAE, examining their properties and potential benefits. Additionally, it will describe the use of pre-, intra-, and postprocedural imaging-particularly magnetic resonance imaging and other modalities-to optimize GAE outcomes.
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http://dx.doi.org/10.1055/s-0044-1788029 | DOI Listing |
Br J Anaesth
January 2025
Department of Theatres, Anaesthesia and Perioperative Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK; Faculty of Life Sciences and Medicine, King's College London, London, UK.
Total knee arthroplasty is a life-changing surgical procedure that is associated with a high incidence of severe postoperative pain. Key to enhancing recovery after surgery is effective analgesia and early mobilisation. Innovations in motor-sparing regional anaesthesia techniques that have improved recovery include targeted surgical local infiltration analgesia, adductor canal blockade, genicular nerve blocks, and the infiltration between the popliteal artery and posterior capsule of the knee (iPACK) block.
View Article and Find Full Text PDFOchsner J
January 2024
Department of Anesthesiology, Super Specialty, MGM Medical College, Indore, India.
Knee osteoarthritis is a chronic degenerative disease associated with pain and decreased mobility that affects advanced-age individuals, thus causing further debilitation. Radiofrequency ablation can benefit patients who are not ideal candidates for surgical intervention and for whom conservative management has been unsatisfactory. Currently, radiofrequency ablation is performed using either ultrasonography or fluoroscopy.
View Article and Find Full Text PDFArch Orthop Trauma Surg
December 2024
Department of Burn, Ruijin Hospital Affliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: Clinically, there has been increasing employment of the medial femoral condyle flap. Pigs have been employed as a model of the medial femoral condyle flap. However, related anatomical studies from the perspective of comparative medicine are rare.
View Article and Find Full Text PDFZhonghua Yi Xue Za Zhi
December 2024
Department of Interventional and Vascular Surgery, the Third Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou213003, China.
To assess the efficacy and safety of genicular artery embolization (GAE) in the management of pain secondary to knee osteoarthritis (KOA). Literature search was conducted on PubMed, Web of Science, Cochrane Library, Embase, and Wanfang databases to collect literatures related to KOA, GAE and therapeutic effects. The search period was from the inception of the databases to July 2024.
View Article and Find Full Text PDFJ Clin Med
November 2024
Center for X-Ray Analytics, Empa-Swiss Federal Laboratories for Materials Science and Technology, Überlandstrasse 129, 8600 Dübendorf, Switzerland.
: The focus of this review is on the imaging techniques used to visualize the meniscal vascular network and arteries in clinical, human ex vivo, and animal model applications. For this purpose, research articles from the past decade that have imaged the vascular network of the meniscus and/or the genicular and popliteal arteries were identified according to established PRISMA statement standards. : Various imaging modalities, including magnetic resonance imaging, micro-computed tomography, and optical and fluorescence microscopy, were included and compared based on the type of visualization, imaging resolution, and range of vessel size detection.
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