Using methyl 2-cyano-3,4--12(13),4(23)-diene-ursolate as a starting scaffold a series of 3-oxo-24-nor-ursolate and A--ursanes holding hydroxy-, furoyloxy-, -tosyloxy- as well as aldehyde fragments at C24 that possess cytotoxic activity has been synthesised. The structures of the new ursanes were confirmed by detailed spectral data analysis. The chemoselectivity of methyl 2-cyano-3,4--12(13),4(23)-diene-ursolate oxidation involving the double bond in the A cycle was observed.
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| http://dx.doi.org/10.1080/14786419.2024.2394093 | DOI Listing |
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