AI Article Synopsis
- - The extracellular matrix (ECM) of solid tumors hinders the effectiveness of CD8 T and natural killer (NK) cells by restricting their movement and altering their functions.
- - Physical barriers created by the tumor ECM directly affect how these immune cells interact with cancer cells, obstructing effective immune response.
- - To enhance solid tumor immunotherapy, it's important to focus on the interactions between immune cells, cancer cells, and the ECM, using advanced bioengineering tools like 3D ECMs and microfluidics for research and treatment screening.
Article Abstract
The extracellular matrix (ECM) of solid tumors impacts the antitumor activities of CD8 T and natural killer (NK) cells in a variety of ways. Cell motility is restricted by the tumor ECM which creates physical barriers. The tumor ECM directly alter the phenotypes and functions of cytotoxic lymphocytes, and indirectly influences immunological synapse-mediated interactions between cytotoxic lymphocytes and cancer cells. Therefore, strategies to improve solid tumor immunotherapy should be established by considering complex ternary interactions between cytotoxic lymphocytes, cancer cells, and the tumor ECM. Novel bioengineering tools approximating key characteristics of the tumor ECM, such as in vitro reconstituted 3D ECMs and microfluidics are valuable from a fundamental study viewpoint and from a translational perspective, aiming to enable systematic screening approaches.
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| http://dx.doi.org/10.1016/j.it.2024.07.009 | DOI Listing |
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