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Resveratrol Upregulates miR-124-3p Expression to Target DAPK1, Regulating the NLRP3/Caspase-1/GSDMD Pathway to Inhibit Pyroptosis and Alleviate Spinal Cord Injury.
J Cell Mol Med
January 2025
Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Yunnan, China.
Currently, an effective treatment for spinal cord injury (SCI) is not available. Due to the irreversible primary injury associated with SCI, the prevention and treatment of secondary injury are very important. In the secondary injury stage, pyroptosis exacerbates the deterioration of the spinal cord injury, and inhibiting pyroptosis is beneficial for recovery from SCI.
View Article and Find Full Text PDFmiR-124-3p may exert its effects in hypertrophic cardiomyopathy by inhibiting cardiomyocyte apoptosis.
Int J Cardiol
December 2024
Department of Cardiac Surgery and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address:
The Benefit of the Optimized Formula of Yinxieling in Psoriasis Vulgaris via Regulation on Autophagy Based on microRNA Expression Profile and Network Pharmacology Analysis.
Drug Des Devel Ther
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State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, People's Republic of China.
Article Synopsis
- - Psoriasis is a common, chronic skin disease that negatively impacts both physical and mental health, leading to significant suffering and high health care costs; the treatment PSORI-CM01 has shown effectiveness over years of clinical use, though its exact mechanisms are not well understood.
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Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury.
Neural Regen Res
September 2024
Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.
JOURNAL/nrgr/04.03/01300535-202409000-00033/figure1/v/2024-01-16T170235Z/r/image-tiff We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain injury. However, its impact on neuronal endoplasmic reticulum stress following repetitive mild traumatic brain injury remains unclear.
View Article and Find Full Text PDFCatalpol antagonizes LPS-mediated inflammation and promotes osteoblast differentiation through the miR-124-3p/DNMT3b/TRAF6 axis.
Acta Histochem
January 2024
Department of Orthopaedics, The People's Hospital of Liaoning Province, Shenyang 110016, Liaoning, People's Republic of China. Electronic address:
Background: Dysregulated inflammation and osteoblast differentiation are implicated in osteoporosis. Exploring the activity of catalpol in inflammation and osteoblast differentiation deepens the understanding of osteoporosis pathogenesis.
Methods: LPS was used to treated hFOB1.
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