AI Article Synopsis
- A study on RSV in England shows a need for better prevention strategies for respiratory syncytial virus (RSV) before the age of 2.
- The research involved a large birth cohort and analyzed hospital admission data, finding that a significant number of infants had RSV-related admissions, with notable factors including low birth weight and timing of birth relative to the RSV season.
- Approximately 1 in 91 infants experienced RSV-coded hospital admissions, indicating that the actual burden may be underestimated, highlighting the importance of widespread immunization efforts to protect all infants.
Article Abstract
Background: A granular understanding of respiratory syncytial virus (RSV) burden in England is needed to prepare for new RSV prevention strategies. We estimated the rates of RSV hospital admissions before the age of 2 years in England and described baseline characteristics.
Methods: A birth cohort of all infants born between March 1, 2015, and February 28, 2017 (n = 449,591) was established using Clinical Practice Research Datalink-Hospital Episode Statistics. Case cohorts included infants with admission for (1) RSV, (2) bronchiolitis, (3) any respiratory tract infection (RTI) <24 months and (4) RSV predicted by an algorithm <12 months. Baseline characteristics were described in the case and comparative cohorts (infants without corresponding admission). Cumulative incidence and admission rates were calculated. Multiple linear regression was used to estimate the proportion of RTI healthcare visits attributable to RSV.
Results: The RSV-coded/RSV-predicted case cohorts were composed of 4813/12,694 infants (cumulative incidence: 1.1%/2.8%). Case cohort infants were more likely to have low birth weight, comorbidities and to be born during RSV season than comparative cohort infants, yet >77% were term-healthy infants and >54% were born before the RSV season. During the first year of life, 11.6 RSV-coded and 34.4 RSV-predicted hospitalizations occurred per 1000 person-years. Overall, >25% of unspecified lower RTI admissions were estimated to be due to RSV.
Conclusions: In England, 1 in 91 infants had an RSV-coded admission, likely underestimated by ~3-fold. Most infants were term-healthy infants born before the RSV season. To decrease the total burden of RSV at the population level, immunization programs need to protect all infants.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319075 | PMC |
| http://dx.doi.org/10.1097/INF.0000000000004467 | DOI Listing |
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