Synthesis of the Corrected Structure Assigned to Clonorosin B, an Alkaloid Obtained from the Soil-derived Fungus YRS-06.

J Nat Prod

Guangdong Key Laboratory for Research and the Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong 524023, China.

Published: September 2024

The revised structure, , assigned to the title natural product has been prepared by chemical synthesis using a reaction sequence involving six simple steps starting from 2,3-dimethoxybenzaldehyde and proceeding via intermediates , , and . A comparison of the NMR data acquired on synthetically derived compound with those reported for the natural product reveals an excellent match. Preliminary biological screening of compound along with analogues/precursors , , , , , , and revealed that none exhibited antibacterial, antifungal or cytotoxic effects.

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http://dx.doi.org/10.1021/acs.jnatprod.4c00777DOI Listing

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