A simple model is used to simulate seizures in a population of spiking excitatory neurons experiencing a uniform effect from inhibitory neurons. A key feature is introduced into the model, i.e., a mechanism that weakens the firing thresholds. This weakening mechanism adds memory to the dynamics. We find a seizure-prone state in a "mode-switching" phase. In this phase, the system can suddenly switch from a "healthy" state with small scale-free avalanches to a "seizure" state with almost periodic large avalanches ("seizures"). Simulations of the model predict statistics for the average time spent in the seizure state (the seizure "duration") that agree with experiments and theoretical examples of similar behavior in neuronal systems. Our study points to. different connections between seizures and fracture and also offers an alternative view on the type of critical point controlling neuronal avalanches.
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http://dx.doi.org/10.1103/PhysRevE.110.014401 | DOI Listing |
Abdom Radiol (NY)
January 2025
Department of Radiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Objective: This study investigates the diagnostic value of Vesical Imaging Reporting and Data System (VI-RADS) in biparametric MRI (bp-MRI) for the detection of muscular infiltration in bladder cancer, and to investigate whether apparent diffusion coefficient (ADC) value can function as a potential indicator of bp-MRI VI-RADS for patient benefit.
Materials And Methods: This single-center retrospective study enrolled 81 patients with pathologically confirmed bladder cancer from October 2019 to November 2021. Two readers independently scored the T2-weighted images and diffusion-weighted images of each index lesion based on the VI-RADS criteria, subsequently deriving the bp-MRI VI-RADS scores.
J Chem Phys
January 2025
Department of Chemistry, Columbia University, New York, New York 10027, USA.
In this work, we investigate anharmonic vibrational polaritons formed due to strong light-matter interactions in an optical cavity between radiation modes and anharmonic vibrations beyond the long-wavelength limit. We introduce a conceptually simple description of light-matter interactions, where spatially localized cavity radiation modes couple to localized vibrations. Within this theoretical framework, we employ self-consistent phonon theory and vibrational dynamical mean-field theory to efficiently simulate momentum-resolved vibrational-polariton spectra, including effects of anharmonicity.
View Article and Find Full Text PDFCancer Sci
January 2025
Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment (TME). Given their various roles in tumor progression and treatment resistance, CAFs are promising therapeutic targets in cancer. The elimination of tumor-promoting CAFs has been investigated in various animal models to determine whether it effectively suppresses tumor growth.
View Article and Find Full Text PDFFront Glob Womens Health
December 2024
Department of Public Health, College of Health Sciences, Woldia University, Woldia, Ethiopia.
Background: Adverse birth outcomes are unfavorable outcomes of pregnancy that are particularly common in low- and middle-income countries. At least one ultrasound is recommended to predict adverse birth outcomes in early pregnancy. However, in low-income countries, imaging equipment and trained manpower are scarce.
View Article and Find Full Text PDFStacks (Portland)
November 2024
Vincent Wildlife Trust, Ledbury HR8 1EP, Herefordshire, UK.
The successful onset of recovery of the European pine marten () in some parts of Britain through range expansion and, more recently translocation for reintroductions, has resulted in a strong interest in reintroduction projects throughout the country. However, the geographic scope and conservation goals of these initiatives are often local and lack consideration of how they fit within the wider context of national-scale pine marten conservation. Here, we aim to maximize conservation benefit strategically at a national level by developing a simple, transparent, and transferable framework based on landscape modelling methods and spatially explicit population viability analyses.
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