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Overlapping and differential neuropharmacological mechanisms of stimulants and nonstimulants for attention-deficit/hyperactivity disorder: a comparative neuroimaging analysis.
Psychol Med
January 2025
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Functional & Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
Background: Psychostimulants and nonstimulants have partially overlapping pharmacological targets on attention-deficit/hyperactivity disorder (ADHD), but whether their neuroimaging underpinnings differ is elusive. We aimed to identify overlapping and medication-specific brain functional mechanisms of psychostimulants and nonstimulants on ADHD.
Methods: After a systematic literature search and database construction, the imputed maps of separate and pooled neuropharmacological mechanisms were meta-analyzed by Seed-based Mapping toolbox, followed by large-scale network analysis to uncover potential coactivation patterns and meta-regression analysis to examine the modulatory effects of age and sex.
Molecular basis for the assembly of the dynein transport machinery on microtubules.
bioRxiv
December 2024
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA.
Cytoplasmic dynein-1, a microtubule-based motor protein, requires dynactin and an adaptor to form the processive dynein-dynactin-adaptor (DDA) complex. The role of microtubules in DDA assembly has been elusive. Here, we reveal detailed structural insights into microtubule-mediated DDA assembly using cryo-electron microscopy.
View Article and Find Full Text PDFMicrogravity and Cardiovascular Health in Astronauts: A Narrative Review.
Health Sci Rep
January 2025
Faculty of Medicine and Health Science Crewe Campus, University of Buckingham Crewe UK.
Background: Space exploration has become a major interest for scientific and medical research. With increasing duration and frequency of manned space missions, it is crucial to understand the impact of microgravity on the cardiovascular health of astronauts. We focus on this relationship by reviewing literature that explores how microgravity affects several hemodynamic parameters and cardiovascular biomarkers.
View Article and Find Full Text PDFBackground And Aims: Family members of patients who are undergoing resuscitation may experience complex psychological challenges, including anxiety, depression, or posttraumatic stress symptoms. Although several studies have identified positive experiences of family members who were given the option to be present during their loved one's resuscitation, the actual impact of family presence during resuscitation on family members remains elusive and needs to be explored comprehensively. This review aims to identify the impact of being present during the resuscitation event of adult patients in in-hospital settings on family members.
View Article and Find Full Text PDFAudiological Features in Patients with Rheumatoid Arthritis: A Systematic Review.
Int J Mol Sci
December 2024
Prospect Clinic for Otorhinolaryngology & Neurology, Kaohsiung 811026, Taiwan.
Hearing impairment in patients with rheumatoid arthritis has been underestimated for decades. Rheumatoid arthritis can affect both the middle ear (specifically, the incudomalleolar and incudostapedial joints) and inner ear (including the cochlea and acoustic nerve) simultaneously. Despite ongoing research, consensus on effective treatments for hearing impairment in these patients remains elusive.
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