From imaging to personalized 3D printed molds in cranioplasty.

Med Eng Phys

Faculty of Engineering, University of Kragujevac, Sestre Janjić 6, Kragujevac 34000, Serbia; Bioengineering Research and Development Centre (BioIRC), Prvoslava Stojanovića 6, Kragujevac 34000, Serbia.

Published: August 2024

Cranioplasty is the surgical repair of a bone defect in the skull resulting from a previous operation or injury, which involves lifting the scalp and restoring the contour of the skull with a graft made from material that is reconstructed from scans of the patient's own skull. The paper introduces a 3D printing technology in creating molds, which are filled with polymethyl methacrylate (PMMA) to reconstruct the missing bone part of the skull. The procedure included several steps to create a 3D model in an STL format, conversion into a G-code which is further used to produce the mold itself using a 3D printer. The paper presents our initial experience with 5 patients who undergone cranioplasty utilizing 3D printed molds. Making a patient-specific model is a very complex process and consists of several steps. The creation of a patient-specific 3D model loading of DICOM images obtained by CT scanning, followed by thresholding-based segmentation and generation of a precise 3D model of part of the patient's skull. Next step is creating the G-code models for 3D printing, after which the actual models are printed using Fused Deposition Modeling printer and PLA material. All surgeries showed good match of the missing bone part and part created using 3D printed mold, without additional steps in refinement. In such a way, 3D printing technology helps in creating personalized and visually appealing bone replacements, at a low cost of the final product.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.medengphy.2024.104215DOI Listing

Publication Analysis

Top Keywords

printed molds
8
patient's skull
8
printing technology
8
missing bone
8
patient-specific model
8
skull
5
imaging personalized
4
printed
4
personalized printed
4
molds cranioplasty
4

Similar Publications

Molding Quality and Biological Evaluation of a Two-Stage Titanium Alloy Dental Implant Based on Combined 3D Printing and Subtracting Manufacturing.

ACS Omega

December 2024

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, Shaanxi, P. R. China.

Metal 3D printing has been used in the manufacturing of dental implants. Its technical advantages include high material utilization and the capacity to form arbitrarily complex structures. However, 3D printing alone is insufficient for manufacturing two-stage titanium implants due to the limited precision in printing titanium alloy parts.

View Article and Find Full Text PDF

This study aimed to develop and validate a cost-effective, customizable patient-specific phantom for simulating external ventricular drain placement, combining image segmentation, 3-D printing and molding techniques. Two variations of the phantom were created based on patient MRI data, integrating a realistic skin layer with anatomical landmarks, a 3-D printed skull, an agarose polysaccharide gel brain, and a ventricular cavity. To validate the phantom, 15 neurosurgeons, residents, and physician assistants performed 30 EVD placements.

View Article and Find Full Text PDF

An integrated magnetoimpedance biosensor microfluidic magnetic platform for the evaluation of the cardiac marker cTnI.

Anal Methods

January 2025

Microelectronic Research & Development Center, School of Mechatronics Engineering and Automation, Shanghai University, Shanghai 200444, China.

An integrated magnetoimpedance (MI) biosensor microfluidic magnetic platform was proposed for the evaluation of the cardiac marker, cardiac troponin I (cTnI). This bioanalyte evaluation platform mainly comprised three external permanent magnets (PMs), one MI element, two peelable SiO film units and a microfluidic chip (MFC). The MI element was made of micro-electro-mechanical system (MEMS)-based multilayered [Ti (6 nm)/FeNi (100 nm)]/Cu (400 nm)/[Ti (6 nm)/FeNi (100 nm)] thin films and designed as meander structures with closed magnetic flux.

View Article and Find Full Text PDF
Article Synopsis
  • Microfluidic channel systems have diverse biomedical applications such as drug delivery and cell culture, with 3D systems providing advanced capabilities to mimic biological processes effectively.
  • The study explores a smart additive manufacturing technique to simplify the creation of these channels, using a 3D printed mold to bypass complicated bonding methods while incorporating dual mixing stages to optimize gradient outcomes.
  • Optimization techniques revealed that specific channel dimensions and flow rates can significantly improve performance, resulting in low production costs of only 1.42 USD per channel.
View Article and Find Full Text PDF

Parameter Optimization and Precision Control of Water-Soluble Support Cores for Hollow Composite Castings Fabricated by Slurry Microextrusion Direct Forming Method.

3D Print Addit Manuf

October 2024

State Key Laboratory of Materials Processing and Die and Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, China.

The optimization of slurry content and forming process parameters has a significant effect in slurry microextrusion direct forming method. In this article, magnesium sulfate monohydrate (MgSO) and polyvinylpyrrolidone (PVP) were used as raw materials to prepare the slurry, and the component ratios of the slurry and the optimization of its forming process were discussed. The optimum slurry content is 64 wt.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!