Family resilience in the neonatal intensive care unit (NICU) is a promising avenue for promoting parental mental health, yet no tool is available to assess it. This study aimed to develop a new scale to measure family resilience in French-speaking parents during the NICU hospitalization and evaluate content validation. This methodological study was conducted in Quebec and included two phases: (a) item development process and (b) content validity evaluation process using successive quantitative and qualitative methods. A total sample of 14 experts evaluated item clarity, relevance, and representativeness on 1-4 rating scales and provided qualitative feedback on scale characteristics. An initial scale of 55 items was developed. Excellent content validity (Scale Content Validity Index > .90) and consensus regarding item selection and scale presentation were achieved. This content-validated 55-item Communication, Organization, and Intrafamilial Beliefs in Neonatology (COCINL) scale should be psychometrically tested in the Quebec NICU parent population.
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http://dx.doi.org/10.1891/JNM-2024-0040 | DOI Listing |
Nat Commun
December 2024
Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
The mechanisms underlying the impact of probiotic supplementation on health remain largely elusive. While previous studies primarily focus on the discovery of novel bioactive bacteria and alterations in the microbiome environment to explain potential probiotic effects, our research delves into the role of living Lactiplantibacillus (formerly known as Lactobacillus) and their conditioned media, highlighting that only the former, not dead bacteria, enhance the healthspan of Caenorhabditis elegans (C. elegans).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Introduction: Alzheimer's disease (AD), primary age-related tauopathy (PART), and chronic traumatic encephalopathy (CTE) all feature hyperphosphorylated tau (p-tau)-immunoreactive neurofibrillary degeneration, but differ in neuroanatomical distribution and progression of neurofibrillary degeneration and amyloid beta (Aβ) deposition.
Methods: We used Nanostring GeoMx Digital Spatial Profiling to compare the expression of 70 proteins in neurofibrillary tangle (NFT)-bearing and non-NFT-bearing neurons in hippocampal CA1, CA2, and CA4 subregions and entorhinal cortex of cases with autopsy-confirmed AD (n = 8), PART (n = 7), and CTE (n = 5).
Results: There were numerous subregion-specific differences related to Aβ processing, autophagy/proteostasis, inflammation, gliosis, oxidative stress, neuronal/synaptic integrity, and p-tau epitopes among these different disorders.
Bioinform Adv
December 2024
School of Biology and Environmental Science, University College Dublin, Dublin, Ireland.
Motivation: Rab GTPases (Rabs) are crucial for membrane trafficking within mammalian cells, and their dysfunction is implicated in many diseases. This gene family plays a role in several crucial cellular processes. Network analyses can uncover the complete repertoire of interaction patterns across the Rab network, informing disease research, opening new opportunities for therapeutic interventions.
View Article and Find Full Text PDFJ Res Adolesc
March 2025
Department of Public Health, Purdue University, West Lafayette, Indiana, USA.
Some Latine youth from rural migrant farmworker communities engage in farmwork to help support themselves and their families. Although research has documented their motives for working and some characteristics of their employment, knowledge about how these youth construct their work in the fields and how such experiences relate to their positive development is needed to depict their holistic experiences. Using mixed methods, we explored youth's farmwork experiences and examined how these experiences relate to youth's prosocial behaviors, civic responsibility, and ego-resiliency.
View Article and Find Full Text PDFJ Res Adolesc
March 2025
University of the Philippines Diliman, Quezon City, Philippines.
This commentary provides a reflection on the impact of the COVID-19 pandemic on adolescents in the context of family dynamics, school environments, peer relationships, and civic engagement. Drawing from four systematic literature reviews, the commentary highlights key findings, such as the long-term effects of COVID-19 on adolescent development, mental health, and academic well-being. The need for future research is emphasized to assess how these cohort effects will evolve over time.
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