AI Article Synopsis
- Some doctors recommend vitamin D and calcium for pregnant women, but it's unclear how they affect early births.
- A study looked at a lot of pregnant women and found that taking vitamin D can increase the chance of early birth, especially if they are also taking calcium.
- The results suggest that taking both supplements between the 3rd and 6th month of pregnancy is linked to higher risks of early birth, and how much the baby weighs can play a role in this risk.
Article Abstract
Background And Aim: Although vitamin D (VD) supplementation or calcium supplementation during pregnancy has become publicly accepted and part of health care behavior, the effect of co-supplementation on preterm birth remains unclear.
Objective: To explore whether the supplementation with vitamin D and calcium during pregnancy is associated with preterm birth.
Methods: The study was the baseline survey from the birth cohort in Jinan, which was built at one month after the baby birth. Preterm birth and monthly VD and calcium supplementation during pregnancy were obtained by the questionnaire. The logistic model was conducted to exam the association. The distributed lag nonlinear model was applied to explore the critical window for the supplements.
Results: Preterm birth occurred in 4.4 % (285/6501) of the study subjects with single live births and the rates were 39.7% and 82.6% for single VD supplementation or calcium supplementation in pregnancy. The adjusted OR (95% CI) for preterm birth was 1.428 (1.115-1.829) related to VD and 0.883 (0.652-1.216) related to calcium. It is interesting to note that the increased risk of preterm birth with VD supplementation during pregnancy was only seen in pregnant women who supplemented with calcium (OR was 1.600) and had a significant increase in preterm birth weight (P = 0.040). Besides, supplementation VD with calcium during pregnancy from the 3rd to 6th month during pregnancy was associated with preterm birth (OR = 1.216, 95% CI: 1.119-1.320; OR = 1.275, 95% CI: 1.152-1.411; OR = 1.279, 95% CI: 1.130-1.446; OR = 1.208, 95% CI: 1.076-1.356). Moreover, birth weight mediated 10.8% of the total effect of supplementation on preterm birth.
Conclusion: Women who supplemented with VD among taking calcium during pregnancy were more likely to experience preterm birth, and birth weight partly mediates the effect. The critical window for association between supplements and preterm birth may be from the 3 to 6 weeks of pregnancy.
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| http://dx.doi.org/10.1016/j.clnesp.2024.08.007 | DOI Listing |
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