The flow rate of a granulate out of a cylindrical container is studied as a function of particle shape for flat and elongated ellipsoids experimentally and numerically. We find a nonmonotonic dependence of the flow rate on the grain aspect ratio a/b. Starting from spheres the flow rate grows and has two maxima around the aspect ratios of a/b≈0.6 (lentil-like ellipsoids) and a/b≈1.5 (ricelike ellipsoids) reaching a flow rate increase of about 15% for lentils compared to spheres. For even more anisometric shapes (a/b=0.25 and a/b=4) the flow rate drops. Our results reveal two contributing factors to the nonmonotonic nature of the flow rate: both the packing fraction and the particle velocity through the orifice are nonmonotonic functions of the grain shape. Thus, particles with slightly nonspherical shapes not only form a better packing in the silo but also move faster through the orifice than spheres. We also show that the resistance of the granulate against shearing increases with aspect ratio for both elongated and flat particles; thus change in the effective friction of the granulate due to changing particle shape does not coincide with the trend in the flow rate.
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http://dx.doi.org/10.1103/PhysRevLett.133.058201 | DOI Listing |
Am J Cancer Res
December 2024
Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Chang Gung University Taoyuan 33305, Taiwan.
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated cancer, and immune checkpoint inhibitors (ICIs) have shown efficacy in its treatment. The combination of chemotherapy and ICIs represents a new trend in the standard care for metastatic NPC. In this study, we aim to clarify the immune cell profile and related prognostic factors in the ICI-based treatment of metastatic NPC.
View Article and Find Full Text PDFJ Blood Med
January 2025
Department of Blood Transfusion of Yong-chuan Hospital, Chongqing Medical University, Chongqing, 402160, People's Republic of China.
Purpose: To study the platelet adhesion and aggregation behaviour of late pregnancy women under arterial shear rate using microfluidic chip technology and evaluate the risk of thrombosis in late pregnancy.
Methods: We included pregnant women who were registered in the obstetrics department of our hospital between January 2021 and October 2022 and underwent regular prenatal examinations. Blood samples were collected at 32-35 weeks of gestation for routine blood tests and progesterone, oestradiol, and platelet aggregation function.
Front Med (Lausanne)
December 2024
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Objective: This paper aims to evaluate the disparities in efficacy and safety across various oral Chinese patent medicines for the treatment of benign prostatic hyperplasia (BPH), using a frequency-based reticulated meta-analysis.
Methods: The researchers searched the following databases: Web of Science, PubMed, Excerpta Medical Database (Embase), Cochrane Library, China Knowledge Network (CNKI), China Biomedical Literature Service System (SinoMed), Wanfang Data Knowledge Service Platform and China Science and Technology Periodicals Database (VIP). Besides, the researchers collected all randomized controlled trials (RCTs) of oral Chinese patent medicines, as well as simple preparations and simple preparations for benign prostatic hyperplasia from the establishment of the database until July1, 2024.
MethodsX
June 2025
Department of Materials Science and Engineering, Norwegian University of Science and Technology (NTNU), NO-7491, Trondheim, Norway.
Construction and experimental validation of electrochemical cells with multiple electrodes in a microfluidic channel is described. Details of the fabrication of the electrodes and polydimethylsiloxane channel using soft lithography methods are given. Calibration of the collection efficiencies and transit times between electrodes validate the use of these cells for fast electrochemical detection of soluble species.
View Article and Find Full Text PDFCirc Rep
January 2025
Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine Chiba Japan.
Owing to recent advances in early reperfusion and pharmacological therapies, the prognosis of patients with acute myocardial infarction (AMI) has considerably improved over the past decades. However, the mortality rate remains high at ~40-50% after AMI when complicated by cardiogenic shock. Although immediate coronary revascularization of the infarct-related artery has been the only evidence-based treatment, temporary mechanical circulatory support with a microaxial flow pump (Impella) has become another therapeutic option supported by randomized trial data in highly selected patients.
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