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Engineered heart muscle allografts for heart repair in primates and humans.
Nature
January 2025
German Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Cardiomyocytes can be implanted to remuscularize the failing heart. Challenges include sufficient cardiomyocyte retention for a sustainable therapeutic impact without intolerable side effects, such as arrhythmia and tumour growth. We investigated the hypothesis that epicardial engineered heart muscle (EHM) allografts from induced pluripotent stem cell-derived cardiomyocytes and stromal cells structurally and functionally remuscularize the chronically failing heart without limiting side effects in rhesus macaques.
View Article and Find Full Text PDFBaicalein-loaded porous silk fibroin microspheres modulate the senescence of nucleus pulposus cells through the NF-κB signaling pathway.
Colloids Surf B Biointerfaces
January 2025
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou 510130, PR China; Guangzhou University of Chinese Medicine Postdoctoral Research Station, Guangzhou 510130, PR China. Electronic address:
Intervertebral disc degeneration (IVDD), an age-associated degenerative condition, significantly contributes to low back pain, thereby adversely affecting individual health and quality of life, while also imposing a substantial societal burden. Baicalein, a natural flavonoid derived from Scutellaria baicalensis Georgi, demonstrates a range of pharmacological activities, including antioxidant, anti-inflammatory, anti-tumor, and antibacterial properties. This positions it as a promising candidate for the treatment of IVDD through intradiscal drug delivery.
View Article and Find Full Text PDFActivating Reversible V/V Redox Couple in NASICON-Type Phosphate Cathodes by High Entropy Substitution for Sodium-Ion Batteries.
Small
January 2025
Key Laboratory of Materials Physics, Institute of Solid State Physics, HFIPS, Chinese Academy of Sciences, Hefei, 230031, P. R. China.
Vanadium-based Na superionic conductor (NASICON) type materials (NaVM(PO), M = transition metals) have attracted extensive attention when used as sodium-ion batteries (SIBs) cathodes due to their stable structures and large Na diffusion channels. However, the materials have poor electrical conductivity and mediocre energy density, which hinder their practical applications. Activating the V/V redox couple (V/V≈4.
View Article and Find Full Text PDFRepetitive Transcranial Magnetic Stimulation for the Treatment of Complex Regional Pain Syndrome: A Pilot Study.
J Pain Res
January 2025
School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada.
Purpose: Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition characterized by sensory, motor, and autonomic dysfunction with a world-wide prevalence of 26.2 per 100,000 people per year and is 3 to 4 times more prevalent in females. Repetitive transcranial magnetic stimulation (rTMS) has shown to be beneficial for pain relief in neuropathic pain and initial evidence in CRPS is promising, but studies are limited.
View Article and Find Full Text PDFLocal Structure Distortion in Mn, Zn Doped Cu₂V₂O₇: Supercapacitor Performance and Emergent Spin-Phonon Coupling.
Adv Mater
January 2025
Department of Physics, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India.
Supercapacitors are rapidly gaining attention as next-generation energy storage devices due to their superior power and energy densities. This study pioneers the investigation of Mn/Zn co-doping in α-Cu₂V₂O₇ (CVO) to enhance its performance as a supercapacitor electrode material. Structural and local Structural properties of Mn/Zn co-doped CVO have been investigated through X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), X-ray Photoelectron Spectroscopy (XPS), and X-ray Absorption Spectroscopy (XAS), revealing significant distortions that enhance supercapacitor performance.
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