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Methodological Insights on Biomarker-Based Patient Selection: A Review of Scientific Advice Procedures at the European Medicines Agency.
Clin Pharmacol Ther
January 2025
Data Analytics and Methods Task Force, European Medicines Agency, Amsterdam, The Netherlands.
Biomarkers play a pivotal role in the selection and enrollment of trial participants. Particularly, predictive biomarkers help tailor medical care to individual patients; however, also prognostic biomarkers require consideration at the design stage. At the time of initiating a clinical trial, there may be uncertainty about whether a biomarker is predictive or prognostic, and the trial design may need to account for this.
View Article and Find Full Text PDFProposals for the Implementation of a Multidimensional Platform That Allows the Advancement of Oncology Nursing in the Latin American Environment (The INCREASE Proposal).
JCO Glob Oncol
January 2025
Direction of Research and Education, Luis Carlos Sarmiento Angulo Cancer Treatment and Research Center-CTIC/El Bosque University, Bogotá, Colombia.
Purpose: Cancer constitutes a significant global health challenge, with projections indicating a continued increase in its prevalence in the foreseeable future. This trend is particularly pronounced in Latin America (LATAM), where the cancer burden has increased substantially over the coming decades. Concurrently, nursing, which represents the largest segment of the health care workforce globally, is important for addressing the multifaceted challenges posed by cancer care, particularly in low- and middle-income countries (LMICs).
View Article and Find Full Text PDFDevelopment and validation of a search strategy and an automated classifier for retrieving temporomandibular disorders studies.
J Oral Facial Pain Headache
June 2024
Orofacial Pain & TMD Program, Faculty of Odontology, Andres Bello University, 8370133 Santiago, Chile.
The objective was to develop and evaluate a comprehensive search strategy (SS) and automated classifier (AC) for retrieving temporomandibular disorders (TMD) research articles. An initial version of SS and AC was created by compiling terms from various sources, including previous systematic reviews (SRs) and consulting with TMD specialists. Performance was assessed using the relative recall (RR) method against a sample of all the primary studies (PS) included in 100 TMD-related SRs, with RR calculated for both SS and AC based on their ability to capture/classify TMD PSs.
View Article and Find Full Text PDFRisk Communication and Community Engagement (RCCE) implementations to control cholera outbreak in Oromia region, Ethiopia.
Trop Med Health
January 2025
School of Medical Laboratory Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.
Background: Oromia regional state experiencing cholera outbreaks in a protracted pattern despite various interventions at local and regional levels. This study aimed to examine the implementation of Risk Communication and Community Engagement (RCCE) activities for cholera outbreak control in the region.
Methods: We conducted a quantitative and qualitative mixed-method study.
Exploring nursing students' learning experiences within tripartite meetings in nursing home clinical placements: a qualitative study using video-stimulated recall interviews.
BMC Nurs
January 2025
Department of Health and Nursing Science, Faculty of Health and Sport Sciences, University of Agder, Grimstad, Norway.
Background: Nursing students' clinical learning is premised on experiences in clinical placements in nurse education, with the processes and outcomes of tripartite meetings among the student, nurse preceptor and teacher being central components. The tripartite meetings form the basis and framework for stakeholders' dialogue and collaboration and have the central purpose of facilitating student learning and development and assessing the students' achievement against predetermined learning outcomes for the placement period. Students' experiences with tripartite meetings seems to be an underexplored field, and therefor this study aimed to explore first-year nursing students' learning experiences within tripartite clinical placement meetings in nursing homes.
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