Electrochemical Trifluoromethylthiolation/Cyclization of -Arylacrylamides with AgSCF: Access to SCF-Containing Oxindoles.

J Org Chem

Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, Shanghai University of Electric Power, Shanghai 200090, China.

Published: September 2024

An environmentally friendly electrochemical strategy for the synthesis of SCF-containing oxindoles was developed. This electrochemical transformation was accomplished through a cascade trifluoromethylthiolation/cyclization of -acrylamides with AgSCF, obviating the requirement for external oxidants. A variety of functional groups were well tolerated in this transformation.

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Source
http://dx.doi.org/10.1021/acs.joc.4c00433DOI Listing

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