AI Article Synopsis
- This study introduces a new method using chiral phosphoric acid to catalyze an efficient and selective reaction called asymmetric reductive amination involving biaryl dialdehydes.
- The approach includes a desymmetrization step followed by kinetic resolution to produce axially chiral aryl aldehydes.
- The resulting products exhibit high optical purity, making this process significant for creating complex chiral molecules.
Article Abstract
Herein we present an efficient chiral phosphoric-acid-catalyzed atropoenantioselective asymmetric reductive amination of biaryl dialdehydes. The process involves desymmetrization and the following kinetic resolution, with a wide range of axially chiral aryl aldehydes obtained with high optical purities.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.4c02540 | DOI Listing |
Publication Analysis
Top Keywords
asymmetric reductive
8
reductive amination
8
axially chiral
8
chiral aryl
8
aryl aldehydes
8
catalytic asymmetric
4
amination axially
4
aldehydes desymmetrization/kinetic
4
desymmetrization/kinetic resolution
4
resolution cascade
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!