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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11407807 | PMC |
| http://dx.doi.org/10.1097/CM9.0000000000003215 | DOI Listing |
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LEAP2 ameliorates high fat diet-impaired glucose tolerance and enhances glucose-stimulated insulin secretion from β cells through PPARγ signal pathway.
Chin Med J (Engl)
August 2024
Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.
Loss of LEAP-2 alleviates obesity-induced myocardial injury by regulating macrophage polarization.
Exp Cell Res
September 2023
Pediatrics, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, PR China. Electronic address:
Article Synopsis
- Obesity is a major public health concern linked to heart problems, particularly subclinical myocardial injury, which increases heart failure risk; this study investigates mechanisms behind this issue.
- Mice were fed a high-fat diet to create an obesity model, and researchers measured various health indicators and assessed inflammation and macrophage behavior related to heart injury.
- The study found that reducing LEAP-2 levels improved heart health in obese mice by reducing inflammation and promoting a beneficial macrophage type (M2), suggesting that targeting LEAP-2 might be a strategy to mitigate obesity-related heart damage.
Liver Expressed Antimicrobial Peptide 2 is Associated with Steatosis in Mice and Humans.
Exp Clin Endocrinol Diabetes
August 2021
Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Background And Aims: Liver expressed antimicrobial peptide 2 (LEAP2) is recently identified as a regulator in energy metabolism. This study aims to 1) investigate the role of leap2 in hepatic steatosis in C57BL/6 mice; 2) evaluate the association between circulating LEAP2 levels and liver fat contents in a hospital based case-control study.
Methods: The rodent experiment: western blotting and qPCR were performed to evaluate leap2 levels, lipid metabolism pathways and insulin signaling.
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