AI Article Synopsis
- - Stress levels have increased significantly during the pandemic, leading to issues like depression and anxiety, and researchers want to explore salivary α-amylase as a potential biomarker for measuring stress, especially in disabled individuals.
- - A study involving 200 participants (100 controls and 100 disabled individuals) assessed salivary α-amylase levels from stimulated and unstimulated saliva samples, revealing significant differences in enzyme levels between controls and disabled groups.
- - Findings indicated that mentally disabled individuals had the lowest salivary α-amylase levels, suggesting variations based on disability type and gender, and highlighting the need for further research to understand how these salivary changes affect overall health.
Article Abstract
Background: Stress is faced by every individual in their day-to-day life activities. During pandemic, most people have experienced multiple episodes of depression, anxiety, and insomnia. Several medical and dental problems are reported with stress and the fastest and easiest way to study and investigate is through body fluids, mainly saliva. Hence, we aim to study salivary α amylase in disabled individuals and hypothesize that salivary α amylase could be a reliable stress biomarker in disabled individuals.
Materials And Methods: Cross-sectional study was conducted including 200 individuals grouped into controls (100) and disabled individuals (100). Disabled individuals were further grouped into physically (50) and mentally (50) disabled. Stimulated and unstimulated saliva was collected from all the participants and were investigated for salivary α-amylase by direct substrate method. The enzyme activity was analyzed using a spectrophotometer and the obtained were analyzed statistically.
Result: Salivary α-amylase showed significant difference between controls and disabled group (p = 0.000). Salivary α-amylase was least in the mentally disabled group compared to physically disabled group. Age related comparison of salivary α-amylase was higher in physically disabled whereas gender related comparison showed females in physically disabled group to be more affected than controls.
Conclusion: Saliva, the easy and most researched fluid, is rich in salivary α-amylase. Salivary α-amylase is a potential biomarker to assess stress. Further diagnostic studies are required to know the salivary changes and their influence on individual general health status.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329072 | PMC |
| http://dx.doi.org/10.4103/jomfp.jomfp_462_23 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A step towards non-invasive diagnosis of diabetes mellitus using synthesized MOF-MXene hybrid material with extended gate field-effect transistor integration.
J Mater Chem B
December 2024
Laboratory of Sensors, Energy and Electronic devices (Lab SEED), Department of Physics and Nanotechnology, SRMIST, Kattankulathur 603203, Tamil Nadu, India.
The increasing demand for non-invasive and non-enzymatic glucose sensors is driven by the objective of eliminating the need for blood pricks from the body and enabling enzyme-free detection of glucose for diagnosing diabetes mellitus. To address this need, we synthesized Ni MOF-MXene (Ni) hybrid material through a one-pot synthesis method, which acts as a catalyst to detect salivary glucose using an extended gate field effect transistor (EGFET) method. The resulting sensor exhibits good selectivity towards glucose over common interfering molecules such as sucrose, fructose, maltose, uric acid, and ascorbic acid under physiological conditions in saliva.
View Article and Find Full Text PDFColorimetric Hybridization Sensor for DNA Mimic of a SARS-CoV-2 RNA Marker: Direct and Inverse Bioanalysis.
ACS Meas Sci Au
December 2024
Department of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078, United States.
This article presents a colorimetric visual biosensor designed for direct application in undiluted biofluids, which holds significant promise for point-of-need applications. Unlike traditional biosensors that struggle with heavily diluted sample matrices, the presented biosensor does not require any instrumentation or trained personnel, making it highly practical. The sensor features an oligonucleotide probe covalently attached to magnetically separable magnetite (FeO) particles.
View Article and Find Full Text PDFResting state EEG delta-beta amplitude-amplitude coupling: a neural predictor of cortisol response under stress.
Cogn Neurodyn
December 2024
Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Unlabelled: Stress is ubiquitous in daily life. Subcortical and cortical regions closely interact to respond to stress. Delta-beta cross-frequency coupling (CFC), believed to signify communication between different brain areas, can serve as a neural signature underlying the heterogeneity in stress responses.
View Article and Find Full Text PDFCase report: Clinical and immunohistochemical manifestations of suspected Sjogren's disease in a dog.
Front Vet Sci
November 2024
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Sjogren's disease, well-described in people, is rarely identified in veterinary species. In people, Sjogren's disease is one of the most common systemic autoimmune disorders with an incidence of 0.5% in the female population.
View Article and Find Full Text PDFSalivary adenoid cystic carcinoma-derived α2,6-sialylated extracellular vesicles increase vascular permeability by triggering ER-stress in endothelial cells and promote lung metastasis.
Cancer Lett
December 2024
Department of Oral Pathology, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Tianjin Road No.2, Huangpu District, Shanghai 200001, China; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Tianjin Road No.2, Huangpu District, Shanghai 200001, China. Electronic address:
Salivary adenoid cystic carcinoma (SACC) tends to metastasize to the lungs in the early stages of the disease. Factors secreted by the primary tumor can induce the formation of a supportive microenvironment in distant organs prior to metastasis, a process known as pre-metastatic niche (PMN) formation. Extracellular vesicles (EVs) participate in PMN formation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!