AI Article Synopsis

  • MG-PRCA is a condition where the bone marrow fails to produce enough red blood cells due to the presence of abnormal proteins from monoclonal plasma cell disorders, leading to anemia.
  • Patients typically show low reticulocyte counts and have normocytic, normochromic anemia as a result.
  • The case discussed highlights successful treatment using a combination of isatuximab, pomalidomide, and dexamethasone after previous treatments had failed.

Article Abstract

Monoclonal gammopathy-associated pure red cell aplasia (MG-PRCA) is characterized by the absence or pronounced hypoplasia of erythroid precursors in the bone marrow, causing reticulocytopenia and a normocytic, normochromic anaemia in a patient with a monoclonal plasma cell dyscrasia. We report here on the successful treatment of MG-PRCA with isatuximab, pomalidomide, and dexamethasone after multiple lines of immunosuppressive and anti-plasma cell-directed treatments.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327726PMC
http://dx.doi.org/10.1002/jha2.964DOI Listing

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