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Neolignans and Diarylnonanoid Derivatives with Anti-inflammatory Activity from Houtt. Seeds. | LitMetric
Houtt. is rich in lignans, neolignans, and diarylnonanoids, with well-documented anti-inflammatory properties. However, there is limited research on the conjugated forms of diarylnonanoids, neolignans, monoterpenes, and others and their anti-inflammatory effects. Our study isolated 33 new compounds (--, and -), including two neolignans, alongside various neolignan-diarylnonanoid, propenylbenzene-diarylnonanoid, 2,3-dimethylbutane-type lignan-diarylnonanoid, and monoterpene-diarylnonanoid conjugates, along with previously reported compounds (, , and -). Their chemical structures were determined via spectroscopic analyses. Compounds , , , , , , , and exhibited potent inhibition of NF-κB/AP1 and IRF signaling induced by TLR agonists. Notably, stereoisomers showed distinct behavior, while 10,11-isomers induced cytotoxicity, and 10,11-isomers produced contrasting effects, especially within group-I compounds.
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