AI Article Synopsis

  • Circoviruses, identified since 1974, cause diseases in humans and various animals, but their origins and transmission pathways are not well understood.
  • This study utilized genome sequences from GenBank and advanced algorithms to analyze the evolution and origins of circovirus, revealing their evolutionary roots trace back to fish.
  • Findings indicate humans, along with mosquitos and other animals, play a role in the virus's spread, and extensive genetic variation occurs through recombination events, helping inform prevention strategies against infections.

Article Abstract

Introduction: Since their identification in 1974, circoviruses have caused clinicopathological diseases in various animal species, including humans. However, their origin, transmission, and genetic evolution remain poorly understood.

Methods: In this study, the genome sequences of circovirus were obtained from GenBank, and the Bayesian stochastic search variable selection algorithm was employed to analyzed the evolution and origin of circovirus.

Results: Here, the evolutionary origin, mode of transmission, and genetic recombination of the circovirus were determined based on the available circovirus genome sequences. The origin of circoviruses can be traced back to fish circovirus, which might derive from fish genome, and human contributes to transmission of fish circovirus to other species. Furthermore, mosquitos, ticks, bats, and/or rodents might play a role as intermediate hosts in circovirus intra- and inter-species transmission. Two major lineages (A and B) of circoviruses are identified, and frequent recombination events accelerate their variation and spread. The time to the most recent common ancestor of circoviruses can be traced back to around A.D. 600 and has been evolving at a rate of 10 substitutions site year for a long time.

Discussion: These comprehensive findings shed light on the evolutionary origin, population dynamics, transmission model, and genetic recombination of the circovirus providing valuable insights for the development of prevention and control strategies against circovirus infections.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327096PMC
http://dx.doi.org/10.3389/fimmu.2024.1332444DOI Listing

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