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| http://dx.doi.org/10.1016/j.xjtc.2024.04.013 | DOI Listing |
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Obesity modulates NK-cell activity via LDL & DUSP1 signaling for Populations with Adverse Social Determinants.
JCI Insight
December 2024
Social Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart Lung and Blood Institute, NIH, Bethesda, United States of America.
African American (AA) women are disproportionally affected by obesity and hyperlipidemia, particularly in the setting of adverse social determinants of health (aSDoH) contributing to health disparities. Obesity, hyperlipidemia, and aSDoH appear to impair Natural Killer cells (NKs). As potential common underlying mechanisms are largely unknown, we sought to investigate common signaling pathways involved in NK dysfunction related to obesity and hyperlipidemia in AA women from under-resourced neighborhoods.
View Article and Find Full Text PDFClinical utility of plasma microbial cell-free DNA sequencing in determining microbiologic etiology of infectious syndromes in solid organ transplant recipients.
Ther Adv Infect Dis
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Baylor College of Medicine, Department of Medicine, Section of Infectious Diseases, Houston, TX 77030-3498, USA.
Background: Metagenomic next-generation sequencing (mNGS) is increasingly being used for microbial detection in various infectious syndromes. However, data regarding the use of mNGS in solid organ transplant recipients (SOTR) are lacking.
Objectives: To describe and analyze real-world clinical impact of mNGS using plasma microbial cell-free DNA (mcfDNA) in SOTR.
Prevalence of Aortoiliac Aneurysms in Solid Organ Transplant Recipients Using the National Inpatient Sample Database.
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Columbia University Irving Medical Center, Division of Vascular Surgery and Endovascular Interventions, New York, NY. Electronic address:
Objective: Single-center studies have suggested that solid organ transplant recipients are at increased risk for arterial aneurysms. Moreover, they describe a more aggressive natural history with increased rates of expansion and rupture. In this exploratory analysis, we aim to assess the frequency of arterial aneurysms in solid organ transplant recipients using a large-scale national database.
View Article and Find Full Text PDFCardiovascular safety of assisted reproductive technology: a meta-analysis.
Eur Heart J
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Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, Milan 20072, Italy.
Background And Aims: The increasing use of assisted reproductive technology (ART) has raised concerns regarding its long-term cardiovascular safety due to potential hormonal imbalances and pro-thrombotic states. This study aimed to assess the long-term cardiovascular risk associated with fertility treatments in women.
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Increases in Donor/Recipient Predicted Heart Mass Ratios Do Not Result in Large Donor Right Ventricles.
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Oregon Health Science University, Knight Cardiovascular Institute. Electronic address:
Pulmonary hypertension puts strain on the right ventricle (RV), leading to the widespread practice of oversizing donor hearts to mitigate complications. However, contemporary evidence for this practice is neutral. We studied the relationship between donor-recipient predicted heart mass (D/R PHM) ratios and increases in donor left ventricle (LV) and right ventricle (RV) mass.
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