Implementation of guideline-directed medical therapy for heart failure: Progress achieved, work ahead!

Eur J Heart Fail

British Heart Foundation Cardiovascular Research Centre, School of Cardiovascular and Metabolic Medicine, University of Glasgow, Glasgow, UK.

Published: October 2024

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http://dx.doi.org/10.1002/ejhf.3438DOI Listing

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Article Synopsis
  • - This study reviewed randomized controlled trials (RCTs) focusing on how traditional Chinese medicine (TCM) treats angina pectoris in coronary heart disease patients after percutaneous coronary intervention (PCI), analyzing various research design elements and outcomes.
  • - A total of 188 RCTs were included, encompassing 15,521 patients, with variations in sample sizes and treatment groups that combined TCM with guideline-directed medical therapy (GDMT).
  • - The study identified common TCM syndromes among patients and categorized numerous outcome indicators used to measure treatment effectiveness, pointing out that most trials lacked a defined follow-up period.
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Effectiveness of Virtual Care Team Guided Management of Hospitalized Patients with HFrEF by Ethnicity.

J Card Fail

December 2024

Stanford University School of Medicine, Division of Cardiovascular Medicine, Palo Alto, CA, USA; Kaiser Permanente San Francisco Medical Center and Division of Research, San Francisco, CA, USA. Electronic address:

Background: IMPLEMENT-HF demonstrated a virtual team-based care strategy was safe and improved prescription of guideline directed medical therapy (GDMT) in hospitalized patients with heart failure and reduced ejection fraction (HFrEF). We evaluated differences in efficacy and safety outcomes by ethnicity in IMPLEMENT-HF.

Methods: IMPLEMENT-HF evaluated a provider-facing virtual team-based care strategy vs.

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Despite significant advances in the management of heart failure with reduced ejection fraction (HFrEF), data concerning older patients remain limited. The purpose of this study was to evaluate the implementation of guideline-directed medical therapy (GDMT) in older patients with HFrEF along with cardiac events and variation in clinical and echocardiographic parameters during follow-up in a heart failure (HF) clinic. We conducted a retrospective observational analysis of patients with HFrEF aged ≥ 80 years who attended an HF clinic between March 2022 and February 2023.

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Bureaucratic Dissonance and Inertia: Barriers to the Effective and Equitable Implementation of Cardiovascular Guideline-Directed Medical Therapy in Canada.

Can J Cardiol

November 2024

Department of Medicine and of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Medicine and of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Cardiology, Capital Health, Halifax, Nova Scotia, Canada; American College of Cardiology, Atlantic Provinces.

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Background: Significant gap remains in the implementation of guideline-directed medical therapy (GDMT) in patients with heart failure after a hospitalization. We aimed to evaluate the use and titration of GDMT at discharge and over a 12-month period after hospital discharge and to identify factors associated with GDMT use and titration.

Methods And Results: The CONNECT-HF (Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure) trial evaluated the effect of a hospital and postdischarge quality improvement intervention in participants with heart failure with reduced ejection fraction.

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