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18F-Fluorodeoxyglucose Uptake in PDGFRA-Mutant Gastrointestinal Stromal Tumors.
JAMA Netw Open
January 2025
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Importance: The D842V platelet-derived growth factor receptor α (PDGFRA) mutation identifies a molecular subgroup of gastrointestinal stromal tumors (GISTs), primarily resistant to standard tyrosine kinase inhibitors and with an overall more indolent behavior. Although functional imaging with 18F-fluorodeoxyglucose-labeled positron emission tomography ([18F]FDG-PET) plays a proven role in GISTs, especially in early assessment of tumor response, less is known about [18F]FDG uptake according to the GIST molecular subtypes.
Objective: To evaluate the degree of [18F]FDG uptake in PDGFRA-mutant GISTs and better define the role of functional imaging in this rare and peculiar subset of GISTs.
Abiotic Stress-Induced Chloroplast and Cytosolic Ca Dynamics in the Green Alga Chlamydomonas reinhardtii.
Plant Cell Environ
January 2025
Department of Biotechnology, University of Verona, Verona, Italy.
Calcium (Ca)-dependent signalling plays a well-characterised role in the perception and response mechanisms to environmental stimuli in plant cells. In the context of a constantly changing environment, it is fundamental to understand how crop yield and microalgal biomass productivity are affected by external factors. Ca signalling is known to be important in different physiological processes in microalgae but many of these signal transduction pathways still need to be characterised.
View Article and Find Full Text PDFToxicity of the Herbicide Roundup Original DI in Tadpoles of and (Anura: Leptodactylidae).
Toxics
December 2024
Tropical Herpetology Lab, Graduate Program in Zoology, Department of Biological Sciences, State University of Santa Cruz, Ilhéus 45662-900, BA, Brazil.
Brazil is one of the largest consumers of herbicides in the world, and glyphosate-based herbicides (e.g., Roundup) are commonly applied in cropland.
View Article and Find Full Text PDFNovel 2-Thiazolylhydrazone with Druggable Properties for Antifungal Application.
J Fungi (Basel)
January 2025
Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Fungal infections have become a growing concern in healthcare, particularly in immunocompromised individuals, with species like , , and posing significant challenges due to rising resistance and limited treatment options. In response, novel antifungal agents are being explored, including thiazolyl hydrazones. This study focuses on the development of a novel thiazolylhydrazone derivative, RW3.
View Article and Find Full Text PDFParametric Design and Mechanical Characterization of a Selective Laser Sintering Additively Manufactured Biomimetic Ribbed Dome Inspired by the Chorion of Lepidopteran Eggs.
Biomimetics (Basel)
December 2024
Digital Manufacturing and Materials Characterization Laboratory, School of Science and Technology, International Hellenic University, 57001 Thermi, Greece.
The current research aims to analyze the shape and structural features of the eggs of the lepidoptera species sp. (Lepidoptera, Nympalidae) and develop design solutions through the implementation of a novel strategy of biomimetic design. Scanning electron microscopy (SEM) analysis of the chorion reveals a medial zone that forms an arachnoid grid resembling a ribbed dome with convex longitudinal ribs and concave transverse ring members.
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