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Nbeal2 Knockout Mice Are Not Protected Against Hypoxia-Induced Pulmonary Vascular Remodeling and Pulmonary Hypertension.
Blood Adv
December 2024
University of Colorado, Denver, Colorado, United States.
Inflammation drives the initiation and progression of pulmonary hypertension (PH). Platelets, increasingly recognized as immune cells, are activated and increased in the lungs of patients with PH. Platelet activation leads to the release of α-granule chemokines, many of which are implicated in PH.
View Article and Find Full Text PDFMICU1 alleviates hypobaric hypoxia-induced myocardial injury through regulating Ca uptake to inhibit mitochondria-dependent apoptosis.
Cell Signal
January 2025
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address:
Aim: High-altitude cardiac injury is a prevalent form of tissue damage resulting from hypobaric hypoxia (HH). MICU1 is a critical modulator of mitochondrial calcium uptake, with significant implications for the regulation of mitochondrial redox homeostasis. This study sought to examine the impact of MICU1 and elucidate the underlying mechanism in myocardial exposed to HH.
View Article and Find Full Text PDFExploring the Impact of Resistance Training at Moderate Altitude on Metabolic Cytokines in Humans: Implications for Adipose Tissue Dynamics.
Int J Mol Sci
October 2024
Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18011 Granada, Spain.
Article Synopsis
- Hypobaric hypoxia (HH) affects oxygen supply and increases energy demands during exercise, which can influence body composition and metabolic responses.
- A study involving 20 trained men showed that 8 weeks of resistance training in HH led to changes in subcutaneous adipose tissue (SAT) thickness and serum levels of metabolic cytokines, including reductions in IL-6 and irisin.
- The training in HH also boosted IL-15 levels, which correlated with significant reductions in SAT, indicating that exercising under HH may enhance body composition by altering cytokine profiles.
Therapeutic effect of bloodletting on bone deterioration induced by hypobaric hypoxia in young rats.
Bone
January 2025
Department of Endocrinology and Metabolism, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Chengdu, China. Electronic address:
Article Synopsis
- High-altitude environments can lead to bone density loss, and understanding how this happens is crucial for developing treatments; this study investigated bone changes in young rats exposed to low oxygen conditions and the effects of bloodletting therapy.
- Male juvenile Sprague-Dawley rats were placed in simulated high-altitude conditions for 12 weeks, with some receiving a weekly bloodletting treatment, and various techniques were used to analyze their bone structure.
- Results showed a significant decrease in bone quality due to low oxygen, with changes in specific bone-related proteins, but bloodletting's overall impact on bone structure was minimal despite some regulatory effects on gene expression.
Effects of intermittent exposure to hypobaric hypoxia and cold on skeletal muscle regeneration: Mitochondrial dynamics, protein oxidation and turnover.
Free Radic Biol Med
November 2024
Department of Cell Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain.
Muscle injuries and the subsequent regeneration events compromise muscle homeostasis at morphological, functional and molecular levels. Among the molecular alterations, those derived from the mitochondrial function are especially relevant. We analysed the mitochondrial dynamics, the redox balance, the protein oxidation and the main protein repairing mechanisms after 9 days of injury in the rat gastrocnemius muscle.
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