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Retinal biomarkers for the risk of Alzheimer's disease and frontotemporal dementia.
Front Aging Neurosci
January 2025
Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.
Purpose: Differentiating between Alzheimer's disease (AD) and frontotemporal dementia (FTD) can be challenging due to overlapping cognitive and behavioral manifestations. Evidence regarding non-invasive and early-stage biomarkers remains limited. Our aim was to identify retinal biomarkers for the risk of AD and FTD in populations without dementia and explore underlying brain structural mechanisms.
View Article and Find Full Text PDFUnlabelled: Proton exchange is a fundamental chemical event, and NMR provides the most direct readout of protonation events with site-specific resolution. Conventional approaches require manual titration of sample pH to collect a series of NMR spectra at different pH values. This requires extensive sample handling and often results in significant sample loss, leading to reduced signal or the need to prepare additional samples.
View Article and Find Full Text PDFPortable six-channel laser speckle system for simultaneous measurement of cerebral blood flow and volume with potential applications in characterization of brain injury.
Neurophotonics
January 2025
California Institute of Technology, Department of Electrical Engineering, Pasadena, California, United States.
Significance: Cerebral blood flow (CBF) and cerebral blood volume (CBV) are key metrics for regional cerebrovascular monitoring. Simultaneous, non-invasive measurement of CBF and CBV at different brain locations would advance cerebrovascular monitoring and pave the way for brain injury detection as current brain injury diagnostic methods are often constrained by high costs, limited sensitivity, and reliance on subjective symptom reporting.
Aim: We aim to develop a multi-channel non-invasive optical system for measuring CBF and CBV at different regions of the brain simultaneously with a cost-effective, reliable, and scalable system capable of detecting potential differences in CBF and CBV across different regions of the brain.
Remote management of anaemia in patients with end-stage kidney disease using a wearable, non-invasive sensor.
Clin Kidney J
January 2025
Alio, Inc., Broomfield, CO, USA.
Anaemia is a prevalent complication in patients with end-stage kidney disease (ESKD) undergoing haemodialysis. This study evaluates the accuracy of the Alio SmartPatch™, a non-invasive remote monitoring device, in measuring haemoglobin (Hb) and haematocrit (Hct) levels in haemodialysis patients by comparing its results with standard blood-based laboratory methods. The results from 116 patients across multiple sites in the USA and the Kingdom of Jordan show that SmartPatch measurements align closely with standard blood-based laboratory methods, meeting clinically acceptable limits of agreement.
View Article and Find Full Text PDFCalibration correction to improve registration during cone-beam CT guided histotripsy.
Med Phys
January 2025
Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Background: Histotripsy is a non-invasive, non-ionizing, non-thermal focused ultrasound technique. High amplitude short acoustic pulses converge to create high negative pressures that cavitate endogenous gas into a bubble cloud leading to mechanical tissue destruction. In the United States, histotripsy is approved to treat liver tumors under diagnostic ultrasound guidance but in initial clinical cases, some areas of the liver have not been treated due to bone or gas obstructing the acoustic window for targeting.
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