AI Article Synopsis
- The study aimed to find links between military exposures and the risk of bladder cancer in veterans.
- A total of 25 studies involving over 4.3 million patients were reviewed, focusing on specific military agents that could contribute to cancer risk.
- Results indicated significant bladder cancer risks associated with Agent Orange and depleted uranium, highlighting the need for better screening and prevention protocols for veterans.
Article Abstract
Objective: To investigate potential carcinogenic exposures in military personnel that are implicated in the development of bladder cancer.
Methods: This systematic review aimed to evaluate the association between specific military exposures and bladder cancer risk among veterans. PubMed, Scopus, and Ovid MEDLINE databases were searched in December 2023 for relevant articles. Inclusion criteria comprised retrospective cohort studies, reviews, and observational studies documenting bladder cancer incidence among military populations exposed to specific agents. A total of 25 studies, involving 4,320,262 patients, met the inclusion criteria. Data extraction followed PRISMA guidelines, and a random-effects model was used for data synthesis.
Results: The meta-analysis revealed significant associations between exposure to Agent Orange (HR 1.17 [95% CI: 1.01-1.36], P < .00001) and depleted uranium (HR 2.13 [95% CI: 1.31-3.48], P = .002) with increased bladder cancer risk among veterans. Contaminated drinking water showed a trend towards increased risk (HR 1.25 [95% CI: 0.97-1.61], P = .08).
Conclusion: The findings suggest a possible association between specific military exposures and heightened bladder cancer risk among veterans, emphasizing the necessity for targeted screening protocols and preventive measures. Further research is essential to identify specific carcinogenic agents and prevalence of exposures among veterans, enabling more effective prevention and management strategies.
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| http://dx.doi.org/10.1016/j.urology.2024.08.008 | DOI Listing |
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