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Background: Alzheimer's disease (AD) remains a formidable neurodegenerative challenge, characterized by profound cognitive decline. Despite decades of research, effective disease-modifying therapies are elusive. Recent advances in molecular neuropharmacology have unveiled potential therapeutic targets for AD, offering renewed hope.
View Article and Find Full Text PDFModified Taohong Siwu Decoction Improved Cardiac Function after Myocardial Infarction by Activating PI3K/Akt Signaling Pathway.
Curr Pharm Des
January 2025
Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Introduction: Taohong Siwu decoction (THSWD), a traditional prescription for enhancing blood circulation and eliminating blood stasis, primarily comprises peach kernel, safflower, angelica, chuanxiong, and rehmannia. Modified Taohong Siwu decoction (MTHSWD), an advanced version of THSWD, incorporates additional ingredients such as epimedium, cinnamon, and salvia miltiorrhiza. This addition serves to augment its efficacy in warming yang and promoting blood circulation.
View Article and Find Full Text PDFFabrication of nanoporous anodized aluminum oxide based photonic crystals with multi-band responses in the vis-NIR region.
Nanoscale
January 2025
School of Physics and Optoelectronic Engineering, Beijing University of Technology, Beijing 100124, P. R. China.
Photonic crystals (PC) play a key role in optical field modulation due to their unique photonic band gaps (PBGs). Anodic aluminum oxide (AAO) prepared by pulse anodization is a promising candidate for PC devices. In this research, an AAO-based PC with multi-band was fabricated on a single-slice & single-material film, which exhibits multi-band responses in the visible-to-near-infrared (vis-NIR) region.
View Article and Find Full Text PDFCancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects.
J Biomed Sci
January 2025
Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, VIC, 3084, Australia.
Research into cancer treatment has been mainly focused on developing therapies to directly target cancer cells. Over the past decade, extensive studies have revealed critical roles of the tumour microenvironment (TME) in cancer initiation, progression, and drug resistance. Notably, cancer-associated fibroblasts (CAFs) have emerged as one of the primary contributors in shaping TME, creating a favourable environment for cancer development.
View Article and Find Full Text PDFAutomatic parking trajectory planning in narrow spaces based on Hybrid A* and NMPC.
Sci Rep
January 2025
Commercial Product R&D Institute, Dongfeng Automobile Co., Ltd., Wuhan, 430070, People's Republic of China.
The rapid acceleration of urbanization and the surge in car ownership necessitate efficient automatic parking solutions in constricted spaces to address the escalating urban parking issue. To optimize space utilization, enhance traffic efficiency, and mitigate accident risks, a method is proposed for smooth, comfortable, and adaptable automatic parking trajectory planning. This study initially employs a hybrid A* algorithm to generate a preliminary path, then fits the velocity and acceleration based on a cubic polynomial.
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