AI Article Synopsis
- Endogenous retroviruses (ERVs) are remnants of ancient infections found in vertebrate genomes, passed down to future generations, and can lead to the production of pathogenic viruses through mutations or genetic recombination.
- Researchers characterized the locus ERV-DC8 on chromosome B1 in domestic cats, discovering it to be an infectious provirus capable of infecting various cell lines, including human cells.
- The study identified ERV-DC8 as a Gammaretrovirus that interacts with the feline copper transporter 1 receptor, demonstrating significant integration in domestic cats and underscoring the evolutionary impact and pathogenic potential of ERVs.
Article Abstract
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections in vertebrate genomes and are inherited by offspring. ERVs can produce pathogenic viruses through gene mutations or recombination. ERVs in domestic cats (ERV-DCs) generate feline leukemia virus subgroup D (FeLV-D) through viral recombination. Herein, we characterized the locus ERV-DC8, on chromosome B1, as an infectious replication-competent provirus. ERV-DC8 infected several cell lines, including human cells. Transmission electron microscopy of ERV-DC8 identified the viral release as a Gammaretrovirus. ERV-DC8 was identified as the FeLV-D viral interference group, with feline copper transporter 1 as its viral receptor. Insertional polymorphism analysis showed high ERV-DC8 integration in domestic cats. This study highlights the role, pathogenicity, and evolutionary relationships between ERVs and their hosts.
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| http://dx.doi.org/10.1016/j.bbrc.2024.150521 | DOI Listing |
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