Obesity-associated lymphedematous mucinosis in two patients: An emerging lifestyle disease.

Indian J Dermatol Venereol Leprol

Department of Surgery, Kasturba Medical College, Manipal, Manipal Academy of Higher education, Manipal, Udupi, Karnataka, India.

Published: July 2024

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http://dx.doi.org/10.25259/IJDVL_1316_2023DOI Listing

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Article Synopsis
  • Cutaneous mucinoses are a diverse group of skin conditions caused by the buildup of mucin in different skin layers, including dermis and epidermis.
  • * Major types include lichen myxedematosus and various mucinoses linked to thyroid disease and connective tissue disorders; recent literature highlights new mucinoses in adults.
  • * Two newly identified mucinoses are obesity-associated lymphedematous mucinosis and nodular mucinosis of the breast, along with categories linked to drug exposure and physical trauma.*
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Obesity-associated lymphedematous mucinosis and stasis mucinosis.

Clin Dermatol

November 2021

Unit of Dermatology, Department of Medical Science and Public Health, University of Cagliari, Italy.

Cutaneous dermal mucinoses are a group of conditions characterized by abnormal deposition of mucin (hyaluronic acid and sulfated glycosaminoglycans) in the dermis. They can be classified either as localized or generalized forms and occur primarily or secondarily to systemic disorders. Obesity-associated lymphedematous mucinosis and pretibial stasis mucinosis are uncommon and relatively newly recognized disorders occurring in obese patients or in patients with venous insufficiency.

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Introduction: Stasis mucinosis and obesity-associated lymphedematous mucinosis (OALM) have been described as 2 discrete diagnostic entities.

Case Report: A morbidly obese African American man in his late 60s presented to the emergency room with a 3-month history of swelling of both lower extremities and secondary changes suggestive of lymphedema and venous dermatitis. On physical examination, the patient had severe edema with multiple raised areas of verruciform skin changes and varicosities, diffuse induration, erythema, and scaling.

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