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Naftifine, an effective therapeutic option in limited variety of tinea corporis and cruris: observations from an open label randomized controlled trial.
Clin Exp Dermatol
August 2024
Department of Dermatology, Venereology, and Leprosy; KPC Medical College & Hospital, Kolkata, India.
A Giant Panda's Skin and Hairs Infection of Nannizzia Gypsum on Lumbosacral Region Successfully Treated by Oral Terbinafine and Topic Naftifine-ketoconazole Cream.
Mycopathologia
June 2024
Department of Dermatovenereology, West China Hospital of Sichuan University, Chengdu, China.
Multimodal nanoimmunotherapy engages neutrophils to eliminate Staphylococcus aureus infections.
Nat Nanotechnol
July 2024
Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.
The increasing prevalence of antimicrobial resistance in Staphylococcus aureus necessitates alternative therapeutic approaches. Neutrophils play a crucial role in the fight against S. aureus but suffer from deficiencies in function leading to increased infection.
View Article and Find Full Text PDFCombined Structure- and Ligand-Based Approach for the Identification of Inhibitors of AcrAB-TolC in .
ACS Infect Dis
December 2023
Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia 5000, Australia.
The inhibition of efflux pumps is a promising approach to combating multidrug-resistant bacteria. We have developed a combined structure- and ligand-based model, using OpenEye software, for the identification of inhibitors of AcrB, the inner membrane protein component of the AcrAB-TolC efflux pump in . From a database of 1391 FDA-approved drugs, 23 compounds were selected to test for efflux inhibition in .
View Article and Find Full Text PDFEfficacy and Safety of Naftifine Hydrochloride 2% Gel in Interdigital Tinea Pedis: A Phase III Randomised, Double-Blind, Parallel-Group, Active-Controlled Study in Indian Adult Patients.
Clin Drug Investig
July 2023
Department of Clinical Development & Medical Affairs, Hetero Labs Limited, Hetero Corporate, 7-2-A2, Industrial Estates, Sanath Nagar, Hyderabad, Telangana, India.
Background And Objective: Naftifine, an allylamine, is highly effective against tinea pedis and exhibits relatively greater affinity to skin and nail beds, possibly due to its high lipophilicity. To study the efficacy and safety of naftifine 2% gel in an Indian population, a phase III multicentre double-blind, comparative, parallel-group study was conducted in comparison with miconazole 2% gel in patients with interdigital tinea pedis, with mild to moderate symptoms.
Patients And Methods: Patients presenting with mild to moderate signs and symptoms of interdigital tinea pedis and mycologically confirmed tinea infection were randomised to either naftifine hydrochloride 2% gel (n = 112) or miconazole 2% gel (n = 112) in 1:1 ratio.
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