AI Article Synopsis
- * A review of 295 natural cardenolides isolated from numerous plant species between 2010 and 2023 highlights their phytochemical and biological properties.
- * In vitro and in vivo studies demonstrate that cardenolides possess notable antitumor, antibacterial, and antiviral properties, with a focus on antitumor activities paving the way for potential cancer treatments and drug development.
Article Abstract
Cardenolides are a class of steroidal glycoside compounds that are mainly distributed in plants, have significant physiological activity in the heart, and have been used clinically for over 200 years. To provide a reference for further research and development of these compounds, the phytochemical and biological properties of natural cardenolides (295 compounds in total) isolated between 2010 and 2023 from 17 families and hundreds of species belonging to 70-80 genera were reviewed. In vitro and in vivo studies have indicated that antitumor, antibacterial, and antiviral activities are the most commonly reported pharmacological properties of cardenolides. Antitumor activities have been thoroughly studied to understand their structure-activity relationships, revealing numerous potential anticancer molecules that lay the theoretical foundation for further development of traditional Chinese medicinal herbs and the creation of new drugs.
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| http://dx.doi.org/10.1002/cbdv.202401460 | DOI Listing |
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