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Interval carcinomas in a breast cancer screening program (2007-2018): Characteristics and prognosis.
Radiologia (Engl Ed)
December 2024
Radiólogo emérito, Hospital Universitario Marqués de Valdecilla, Santander, Spain. Electronic address:
Background And Aims: To analyze the radiologic and histologic characteristics of screening and interval cancers diagnosed in the period comprising 2007 through 2018 in a total of six rounds of a population-based breast cancer screening program.
Material And Methods: We analyzed 1395 carcinomas detected at screening and 300 interval carcinomas diagnosed in women aged 50-69 years old who underwent digital mammography every two years during the study period. Screening mammograms were read once.
Fine Needle Aspiration Cytological Diagnosis of Primary Breast Large-Cell Neuroendocrine Carcinoma/Squamous Cell Carcinoma.
Diagn Cytopathol
December 2024
Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China.
Primary breast large-cell neuroendocrine carcinoma (LCNEC)/squamous cell carcinoma (SCC), also referred to as mixed neuroendocrine/non-neuroendocrine neoplasms of the breast (Br-MiNENs), represents an exceedingly rare malignancy. We report the first case of primary breast LCNEC/SCC diagnosed via ultrasound-guided fine-needle aspiration (FNA) biopsy of the left supraclavicular and left internal mammary lymph nodes. The patient, a 40-year-old female, underwent a lumpectomy followed by breast-conserving surgery and was diagnosed with primary breast LCNEC.
View Article and Find Full Text PDFThrombin confers chemotherapeutic resistance by promoting transcriptional induction and post-translational stabilization of pro-survival MCL1 in TNBC.
J Biol Chem
November 2024
School of Biological Sciences, Indian Association for the Cultivation of Science, Kolkata, India. Electronic address:
The association between idiopathic venous thrombosis and occult cancer is widely recognized. However, the comprehensive understanding of how thrombin, generated during the process of thrombosis, possesses the potential to augment the malignant phenotype is still not well understood. The coagulation protease thrombin mediates its effects by cleaving protease-activated receptor 1 (PAR1), a receptor abundantly expressed on the surface of triple-negative breast cancer (TNBC) cells.
View Article and Find Full Text PDFProtein tyrosine phosphatase non-receptor II: A possible biomarker of poor prognosis and mediator of immune evasion in hepatocellular carcinoma.
World J Gastrointest Oncol
September 2024
Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, Anhui Province, China.
Article Synopsis
- - The incidence of primary liver cancer, particularly hepatocellular carcinoma (HCC), is on the rise globally, with China having the highest rates; early detection is crucial as symptoms often appear late in the disease.
- - This study aims to analyze the biological role of Protein Tyrosine Phosphatase Non-Receptor 2 (PTPN2) in HCC using data from The Cancer Genome Atlas (TCGA) and various laboratory methods to assess its diagnostic and prognostic value.
- - Results demonstrate that PTPN2 expression correlates with HCC patient survival and suggests its potential involvement in immune evasion processes in liver cancer.
Occult triple-negative breast cancer in a man with bone metastasis as the first and only manifestation.
Asian J Surg
October 2024
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China. Electronic address:
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