AI Article Synopsis
- Biological agents and small molecule drugs have improved treatment for psoriasis, but there's a gap in understanding how these drugs affect mental disorders (MDs) and vice versa.
- A systematic review analyzed 116 studies, showing that psoriasis medications generally improve MD symptoms while some MD treatments negatively impact psoriasis.
- Notably, TNF-α inhibitors and interleukin inhibitors are more effective than traditional treatments, with secukinumab and ixekizumab showing significant benefits for anxiety and depression, respectively, despite limitations in data standardization.
Article Abstract
Background: The emergence of biological agents and small molecule drugs has revolutionized the treatment landscape for psoriasis, yet there remains a lack of systematic reviews elucidating the efficacy and safety of drugs for patients with psoriasis and mental disorders (MDs). The aim was to systemically evaluate the efficacy and safety of FDA-approved psoriasis drugs on MD symptoms and MD drugs on psoriasis symptoms.
Methods: We conducted comprehensive literature searches of the PubMed, Embase, and Cochrane Library from inception to March 24, 2024, identifying 116 relevant studies for inclusion.
Results: Our review encompasses 62 clinical trials and 54 case reports/series. Analyses of clinical trials revealed a positive impact of psoriasis drugs on MD, with notable exceptions including lithium and benzodiazepine receptor agonists, which exhibited adverse effects on psoriasis. Furthermore, analysis of case reports/series highlighted the efficacy of drugs such as apremilast, etanercept, infliximab, and secukinumab in ameliorating MD symptoms, contrasting with detrimental effects observed with methotrexate (MTX), cyclosporine, adalimumab, and secukinumab. Notably, tumor necrosis factor alpha (TNF-α) inhibitors and interleukin inhibitors demonstrated superior efficacy compared to conventional treatments. In the anxiety group, secukinumab showed the largest effective size as assessed by the Hospital Anxiety and Depression Scale - Anxiety (HADS-A) index; In the depression group, ixekizumab showed the largest effective size assessed by the 16-item Quick Inventory of Depressive Symptomology - Self-Report (QIDS-SR16) index.
Limitations: The extracted data cannot be meta-analyzed, as the measurement scale is not uniform.
Conclusions: This systematic review provides robust evidence regarding treatment options for individuals with psoriasis and MD, emphasizing the potential benefits of specific drugs in managing both conditions concurrently.
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| http://dx.doi.org/10.1016/j.jad.2024.08.077 | DOI Listing |
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